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PURPOSE to evaluate the efficacy of monoclonal anti-tumor necrosis factor alpha antibody infliximab in treatment of refractory Wegene's granulomatosis. Clinical manifestations of Wegener's granulomatosis at the time of infliximab initiation were: proptosis of both eyes due to progressive retrobulbar granulomas, visual impairment, optic disc edema,(More)
Necrotizing herpetic retinopathies are serious, usually rapidly progressive diseases of retina. Three well defined syndromes can be outlined: acute retinal necrosis, progressive outer retinal necrosis and CMV retinitis. Two cases of acute retinal necrosis, where the clinical picture was probably influenced by the corticosteroid use are described. The(More)
PURPOSE To assess the diagnostic yield of vitreous fluid analysis and the therapeutic effect of pars plana vitrectomy in patients with suspected intraocular inflammation. METHODS During 2004-2008, pars plana vitrectomy was performed in 89 patients (101 eyes) out of 1233 patients with uveitis. Vitreous specimens were analyzed by cytologic and(More)
The authors present the case of a female patient who, following complicated surgery, developed endogenous endophthalmitis. Based on the clinical picture and microscopic finding in the punctuate of the affected vitreous body the diagnosis of endogenous mycotic endophthalmitis was established. The treatment of the condition is based on a combination of local(More)
To present a possible coincidence of cytomegalovirus retinitis and intraocular lymphoma in a patient with systemic non-Hodgkin’s lymphoma. A 47-year-old woman presented with decreased visual acuity associated with white retinal lesions in both eyes. A history of pneumonia of unknown aetiology closely preceded the deterioration of vision. Five years(More)
BACKGROUND Acute retinal necrosis is a sight-threatening disease caused by the group of herpesviruses. The aim of this paper is to report a case of acute retinal necrosis following ocular trauma in a patient initially treated with vaso-active drugs and corticosteroids for presumed ocular ischemic syndrome. CASE PRESENTATION A 51-years-old otherwise(More)
PURPOSE To describe a case report of a 23-year-old patient with retinitis pigmentosa (RP) misdiagnosed as uveitis. METHODS A comprehensive eye examination including automated visual field assessment, contrast sensitivity, colour vision discrimination, ultrasound examination (US), spectral domain optical coherence tomography (SD-OCT) and full-field(More)
A mutagenic effect of allylisothiocyanate (AITC) on E. coli WP 67 (trp uvrA polA) was only found in a test with metabolic activation in vitro. Mixed function oxidases containing cytochrome P-450 are not responsible for the conversion of AITC to mutagenic products. Liver microsomal fractions of rat, mouse, chinese hamster, goat and monkey were used for in(More)
AIM To evaluate the course of clinical picture of intraocular lymphoma, possibilities of examination of this disease and the association with general symptoms of the non-Hodgkin lymphoma (NHL) in patients with manifestations of uveitis. PATIENTS AND METHODS A retrospective study in 14 patients followed in the period of 1996-2001 in the Center for(More)