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Oestrogens may modulate the activity of the hypothalamic–pituitary–adrenal (HPA) axis. The present study was to investigate whether the activity of the HPA axis in mood disorders might be directly modulated by oestrogens via oestrogen receptors (ORs) in the corticotropin-releasing hormone (CRH) neurons of the human hypothalamic paraventricular nucleus(More)
We investigated whether low intensity dawn-dusk simulation (DDS), a 'naturalistic' form of light therapy designed to embed sleep in its accustomed phase, could improve the disturbed circadian rest-activity cycle, nocturnal sleep and and/or cognitive functions in dementia. A protocol of 3 weeks each of baseline, treatment and follow-up was completed by 13(More)
The cingulate cortex is regarded as the backbone of structural and functional connectivity of the brain. While its functional connectivity has been intensively studied, little is known about its effective connectivity, its modulation by behavioral states, and its involvement in cognitive performance. Given the previously reported effects on cingulate(More)
Deep sleep is characterised by slow waves of electrical activity in the cerebral cortex. They represent alternating down states and up states of, respectively, hyperpolarisation with accompanying neuronal silence and depolarisation during which neuronal firing resumes. The up states give rise to faster oscillations, notably spindles and gamma activity which(More)
Simultaneous EEG-fMRI combines two powerful neuroimaging techniques, but the EEG signal suffers from severe artifacts in the MRI environment that are difficult to remove. These are the MR scanning artifact and the blood-pulsation artifact--strategies to remove them are a topic of ongoing research. Additionally large, unsystematic artifacts are produced(More)
Although the cognitive and clinical correlates of spontaneous human alpha oscillations as recorded with electroencephalography (EEG) or magnetoencephalography (MEG) are well documented, the dynamics underlying these oscillations is still a matter of debate. This study proposes a data-driven method to reveal the dynamics of these oscillations. It(More)
At CWI (Centrum voor Wiskunde en Informatica) a desk-top Virtual Reality apparatus , the Personal Space Station, was built which enables its users to interact with a computer generated 3D scene by manipulating real-world objects. A mirror reflects the generated scene in such a way that virtual objects seem to coincide with their real-world counterparts, in(More)
The hypothalamic-pituitary-adrenal (HPA) axis plays an important role in sleep. Nevertheless, the association of sleep and its 24-h organization with negative feedback control of the HPA axis has received limited attention in population-based studies. We explored this association in 493 middle-aged persons of the Rotterdam Study, a large population-based(More)
26 27 Sleep, cognition, and behavioural problems in school-age children I Systematic literature review 2 Chapter 2 INTRODUCTION Over the past decades, sleep research has started to unravel the effects of sleep on daytime cognition and behavioural problems. Experimentally induced partial and total sleep deprivation in healthy adults can lead to a host of(More)
Deep sleep is characterized by slow waves of electrical activity in the cerebral cortex. They represent alternating down–states and up–states of, respectively, hyperpolarization with accompanying neuronal silence and de-polarization during which neuronal firing resumes. The up states give rise to faster oscillations, notably spindles and gamma activity(More)