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Under low oxygen tension, cells increase the transcription of specific genes involved in angiogenesis, erythropoiesis, and glycolysis. Hypoxia-induced gene expression depends primarily on stabilization of the alpha subunit of hypoxia-inducible factor-1 (HIF-1alpha), which acts as a heterodimeric trans-activator with the nuclear protein known as the aryl(More)
Under low oxygen tension, cells increase the transcription of specific genes that are involved in angiogenesis, erythropoiesis, and glycolysis. Hypoxia-induced gene expression primarily depends on the stabilization of the a-subunit of hypoxia-inducible factor-1 (HIF-1a), which acts as a heterodimeric transactivator. Our results indicate that stabilization(More)
Under low oxygen tension, cells increase the transcription of specific genes involved in angiogenesis, erythropoiesis, and glycolysis. Hypoxia-induced gene expression depends primarily on stabilization of the subunit of hypoxia-inducible factor-1 (HIF-1 ), which acts as a heterodimeric trans-activator with the nuclear protein known as the aryl hydrocarbon(More)
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