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Nesfatin-1 was first shown to be involved in the control of appetite and energy metabolism in the hypothalamus. Many recent reports have shown nesfatin-1 expression in various tissues including the pituitary gland, but its expression and regulation mechanisms in the pituitary gland are unclear. Therefore, first, we investigated the mRNA and protein(More)
Nesfatin-1, an anorexic nucleobindin-2 (NUCB2)-derived hypothalamic peptide, controls appetite and energy metabolism. Recent studies show that nesfatin-1/NUCB2 is expressed not only in the brain but also in gastric and adipose tissues. Thus, we investigated the distributions of nesfatin-1/NUCB2 in various tissues of male and female mice by real-time PCR,(More)
The pregnancy and abortion process involves a complex mechanism with various immune cells present in the implantation sites and several hormones associated with pregnancy, such as leptin, ghrelin and nesfatin-1. However, the mechanism underlying spontaneous abortion by maternal T helper 17 (Th17) present in the implantation sites and nesfatin-1, which is of(More)
Various conditions can result in scratching behavior and severe itching conditions such as atopic dermatitis can significantly impact on one's quality of life. Because the management of many itching conditions is not necessarily about curing the condition but instead about properly maintaining or controlling the condition, a proper understanding of these(More)
We studied the mechanism by which tributylin acetate (TBT) inhibits the development of T cells in the mouse thymus. After 7 days of oral TBT administration in mice, thymic weights were significantly decreased, and the expression of Troma-1, a thymic cortical epithelial cell marker, was also decreased in TBT-treated mice. The expression of cytokines produced(More)
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