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SON controls cell-cycle progression by coordinated regulation of RNA splicing.
TLDR
It is reported that SON, a large Ser/Arg (SR)-related protein, is a splicing cofactor contributing to efficient splicing of cell-cycle regulators, suggesting its function in efficient cotranscriptional RNA processing. Expand
Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts.
TLDR
In this review, recent advances made involving secondary mutational events and alternative t(8;21) transcripts in relation to understanding AML1-ETO leukemogenesis are surveyed. Expand
Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival.
TLDR
This study is the first to implicate the TLEs as potential tumor suppressor genes in myeloid leukemia, and develops a set of shRNAs directed against each gene in this region. Expand
Calmodulin Binding to the Fas Death Domain
TLDR
It is demonstrated that CaM binds to Fas directly and the CaM-binding site on the cytoplasmic death domain (DD) of Fas is identified and suggested as a novel function of CaM in Fas-mediated apoptosis. Expand
Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis
TLDR
The crucial role of the NHR4 domain in determination of cellular fate during AML1-ETO-associated leukemogenesis is uncovered and identified SON, a DNA/RNA-binding domain containing protein, as a novel NHR3/NHR4-interacting protein. Expand
IFN‐γupregulates apoptosis‐related molecules and enhances Fas‐mediated apoptosis in human cholangiocarcinoma
TLDR
Findings indicate that IFN‐γ modulates the apoptotic pathway by upregulating apoptosis‐related genes, which renders tumorigenic Fas‐low cholangiocarcinoma cells nontumorigenic and sensitive to Fas apoptosis, thus representing a possible therapeutic modality. Expand
The combination of calmodulin antagonists and interferon-gamma induces apoptosis through caspase-dependent and -independent pathways in cholangiocarcinoma cells.
TLDR
It is demonstrated that interferon (IFN)-gamma induces susceptibility to CaM antagonist-mediated apoptosis in human cholangiocarcinoma cells weakly expressing Fas (Fas-low cells), and that susceptibility toCaM antagonists is modulated by IFN-gamma. Expand
Assessing the antioxidant, cytotoxic, apoptotic and wound healing properties of silver nanoparticles green-synthesized by plant extracts.
TLDR
The cytotoxicity of the silver nanoparticles synthesized with Cratoxylum formosum and Mucuna birdwoodiana extracts resulted in apoptotic cell death in A549 cells, and the wound healing activity observed by the cell scratch method on mouse fibroblast cells suggested that the Lindera strychnifolia extract producedsilver nanoparticles with decent activity. Expand
RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis.
TLDR
It is reported that the AML1 DNA-binding domain and the ETO NHR2-dimerization domain, but not the Eto NHR1 domain, are critical for the induction of AML by AML-ETO9a, which is highly leukemogenic in the mouse model. Expand
Fas Binding to Calmodulin Regulates Apoptosis in Osteoclasts*
TLDR
It is shown that a 3-h treatment of mouse osteoclasts with either of the calmodulin antagonists, tamoxifen or trifluoperazine, induces osteoclast apoptosis dose-dependently, and the effects of cal modulin/Fas binding on calmodul antagonist-induced apoptosis may open a new avenue for therapy for osteoporosis. Expand
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