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Structural basis for the auxin-induced transcriptional regulation by Aux/IAA17
This work reports the first structure of the oligomerization domain of IAA17, and describes the key determinant that dictates the switch between homo- and hetero-oligomers, and characterize molecular interactions underlying the homotypic and heterotypic oligomers. Expand
Structural characterization of β-d-(1→3, 1→6)-linked glucans using NMR spectroscopy
Abstract Nondestructive structural analysis of a series of β- d -(1→3, 1→6)-linked glucans (laminaran, curdlan, yeast glucan, scleroglucan, etc.) was performed using two-dimensional NMR spectroscopy.Expand
Plk1-targeted small molecule inhibitors: molecular basis for their potency and specificity
This review focused on discussing the recent development of small-molecule and phosphopeptide inhibitors for their potency and specificity against Plk1, an attractive anti-cancer drug target. Expand
Stereospecific mechanism of DJ‐1 glyoxalases inferred from their hemithioacetal‐containing crystal structures
The mechanism of DJ‐1 glyoxalase provides a basis for understanding the His residue‐based stereospecificity ofDJ‐1 superfamily proteins, and was evaluated by a molecular modeling simulation with methylglyoxal hemithioacetal superimposed on the glyoxylate hemithIOacetal. Expand
Enzymatic Synthesis of Novel Phloretin Glucosides
The application of the UDP-glycosyltransferase from Bacillus licheniformis for the efficient whole-cell biocatalysis of phloretin in engineered Escherichia coli is demonstrated. Expand
Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin
The structure of double-knot toxin (DkTx), a tarantula toxin that activates the heat-activated TRPV1 channel is solved and reveals a novel mode of toxin-channel recognition that has important implications for the mechanism of thermosensation. Expand
Curcuminoids from Curcuma longa and their inhibitory activities on influenza A neuraminidases
The results suggest that the curcuminoids from C. longa may be potential supplemental molecules in the prevention and treatment of disease by influenza viruses. Expand
C-Methylated Flavonoids from Cleistocalyx operculatus and Their Inhibitory Effects on Novel Influenza A (H1N1) Neuraminidase.
Results indicate that C-methylated flavonoids from C. operculatus have the potential to be developed as neuraminidase inhibitors for novel influenza H1N1. Expand
Metabolomic unveiling of a diverse range of green tea (Camellia sinensis) metabolites dependent on geography.
A new approach for non-targeted or global analysis, which is highly reproducible and statistically effective in analysing a diverse range of compounds, was used to better understand the metabolome of Camellia sinensis and determine the influence of environmental factors, including geography, climate, and cultural practices, on tea-making. Expand
Structural determination of the N-glycans of a lepidopteran arylphorin reveals the presence of a monoglucosylated oligosaccharide in the storage protein.
Interestingly, the most abundant oligosaccharide was monoglucosylated Man9-GlcNAc2, which was characterized by normal-phase HPLC, mass spectrometry, Aspergillus saitoi alpha-mannosidase digestion, and 1H 600 MHz NMR spectrometers and may play a role in the folding of arylphorin or in the assembly of hexamers. Expand