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Platycodin D and D3 increase airway mucin release in vivo and in vitro in rats and hamsters.
The results from the present study suggest that platycodin D and D3 are useful as expectorant agents in the treatment of various airway diseases. Expand
Platycodin D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF-alpha in activated RAW 264.7 cells.
A dichotomous regulation of these important proinflammatory mediators by PD and PD3 is suggested, suggesting that PD may stimulate TNF-alpha synthesis or inhibit degradation of T NF-alpha mRNA. Expand
Araloside A, an antiulcer constituent from the root bark of Aralia elata.
Araloside A, a potent inhibitor of gastric lesion and ulcer formation in rats, was isolated from the root bark of Aralia elata through a bioassay-guided separation procedure. The compound exhibitedExpand
Anti-inflammatory activity of prosapogenin methyl ester of platycodin D via nuclear factor-kappaB pathway inhibition.
These compounds exert an anti-inflammatory effect through the regulation of the NF-kappaB pathway, which is suggested to be based on the structure of the sugar substituent or methyl group at the C28-carboxyl position. Expand
Effects of saponins from the root bark of Aralia elata on the transport of chondroitin sulfate in Caco-2 cell monolayers and rats.
The results suggest that SRBAE acts as an efficient absorption enhancer and makes it easier for hydrophilic molecules to penetrate the intestinal epithelium. Expand
Pharmacological study on piperine
Systematic pharmacological studies on piperine have revealed that this compound elicited diverse pharmacological activities; CNS depressant activity characterized by antagonism against electroshockExpand
Saponins and flavonoid glycosides from yellow sweetclover
A new saponin, 3-O-[a-L-rhamnopyranosyl(1→2)-β-D-glucopyranosyl(1→2)-β-D-glucuronopyranosyl]soyasapogenol B carboxylate (6) has been isolated from the medicinal plant yellow sweetclover together withExpand
Activity-guided isolation of saponins from Kalopanax pictus with anti-inflammatory activity.
Two novel saponin components, kalopanaxsaponin A and pictoside A, showed significant anti-inflammatory activity at the oral doses of 50 mg/kg. Expand
Antiinflammatory activity of alpha-hederin methyl ester from the alkaline hydrolysate of the butanol fraction of Kalopanax pictus bark extract.
Three antiinflammatory saponin components were isolated from the alkaline hydrolysate of a butanol-soluble portion of Kalopanax pictus bark extract through an in vivo activity-guided fractionationExpand