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BACKGROUND Acute liver injury (ALI) induced by paracetamol overdose is a well known cause of emergency hospital admission and death. However, there is debate regarding the risk of ALI after therapeutic dosages of the drug.The aim is to describe the characteristics of patients admitted to hospital with jaundice who had previous exposure to therapeutic doses(More)
AIMS Despite progress in anti-emetic treatment, many patients still suffer from chemotherapy-induced nausea and vomiting (CINV). This is a pilot, randomized, double-blind, placebo-controlled phase II clinical trial designed to evaluate the tolerability, preliminary efficacy, and pharmacokinetics of an acute dose titration of a whole-plant cannabis-based(More)
BACKGROUND/AIMS Acute serious liver disease which is unrelated to infectious, obstructive, or metabolic disease is uncommon. Many drugs have been implicated. Data on its epidemiology are scarce. We performed a population-based prospective study of acute serious liver disease in Catalonia (Spain). METHODS A collaborating hospital network was set up. All(More)
BACKGROUND Acute liver injury of uncertain aetiology is often drug related and quantitative information about the associated risk is scarce. AIM To estimate the risk of acute liver injury associated with the use of drugs. METHODS In a population survey study, 126 cases of acute liver injury were prospectively assembled from January 1993 to December(More)
OBJECTIVE Pyrithyldione, a sedative-hypnotic drug with a poor clinical pharmacological development, was associated with anecdotal cases of agranulocytosis in the 1940s in the USA, in the 1960s and 1970s in the ex-Democratic Republic of Germany and in the 1980s in Japan. We describe the estimation of the risk of agranulocytosis associated with its use in(More)
OBJECTIVE To assess participants' knowledge of key aspects about the clinical trials in which they are enrolled, describe the consent process, and assess the importance that investigators give to various aspects of trial information when verbally informing candidates. DESIGN Prospective study based on a structured questionnaire interview of participants(More)
In each of the nine regions of the Dominican Republic a sample of 300 girls was studied: 100 from private schools, 100 from public urban schools, and 100 from public rural schools, making a total of 2700 girls studied on a national scale. Age, menarche, region, and socioeconomic factors were investigated. Age at menarche was obtained by the Statu Quo(More)
The risk of agranulocytosis associated with anti-arrhythmic drugs has been assessed by studying previous drug exposure of all cases collected through a multicentre surveillance network in a defined geographical area during the period 1980-1988. One hundred and eighty-one patients with agranulocytosis (less than 500 granulocytes mm-3 at least in two(More)
INTRODUCTION AND OBJECTIVES The objective of this study was to determine whether a home-based intervention can reduce mortality and hospital readmissions and improve quality of life in patients with heart failure. METHODS A randomized clinical trial was carried out between January 2004 and October 2006. In total, 283 patients admitted to hospital with a(More)