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The nature of dopamine dysfunction in schizophrenia and what this means for treatment.
CONTEXT Current drug treatments for schizophrenia are inadequate for many patients, and despite 5 decades of drug discovery, all of the treatments rely on the same mechanism: dopamine D(2) receptorExpand
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Social cognition and neurocognition as predictors of conversion to psychosis in individuals at ultra-high risk
BACKGROUND While deficits in cognitive functions are frequently reported in psychotic disorders, further longitudinal research is needed to confirm the specific risk factors for the development ofExpand
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Unravelling the Intrinsic Functional Organization of the Human Striatum: A Parcellation and Connectivity Study Based on Resting-State fMRI
As the main input hub of the basal ganglia, the striatum receives projections from the cerebral cortex. Many studies have provided evidence for multiple parallel corticostriatal loops based on theExpand
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Altered resting-state connectivity in subjects at ultra-high risk for psychosis: an fMRI study
BackgroundIndividuals at ultra-high risk (UHR) for psychosis have self-disturbances and deficits in social cognition and functioning. Midline default network areas, including the medial prefrontalExpand
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Predicting Brain Occupancy from Plasma Levels using PET: Superiority of Combining Pharmacokinetics with Pharmacodynamics while Modeling the Relationship
Positron emission tomography (PET) studies of dopamine receptor occupancy can be used to assess dosing of antipsychotics. Typically, studies of antipsychotics have applied pharmacodynamic (PD)Expand
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Abnormal corticostriatal-limbic functional connectivity in obsessive–compulsive disorder during reward processing and resting-state☆
Compulsive behaviors in obsessive–compulsive disorder (OCD) may be related to deficits in reward processing mediated by corticostriatal circuitry, a brain network implicated in the pathophysiology ofExpand
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The relationship between antipsychotic D2 occupancy and change in frontal metabolism and working memory
RationaleThe effects of aripiprazole on cognitive function are obscure, possibly due to the difficulty in disentangling the specific effects on cognitive function from effects secondary to theExpand
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Longitudinal Patterns of Social Functioning and Conversion to Psychosis in Subjects at Ultra-High Risk
  • J. Jang, N. Shin, +7 authors J. Kwon
  • Psychology, Medicine
  • The Australian and New Zealand journal of…
  • 1 September 2011
Objective: Impaired social functioning is one of the defining features of patients with schizophrenia and subjects at ultra-high risk (UHR) for psychosis. This prospective study aimed to investigateExpand
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Dopaminergic function in the psychosis spectrum: an [18F]-DOPA imaging study in healthy individuals with auditory hallucinations.
BACKGROUND The psychosis phenotype appears to exist in the population as a continuum, but it is not clear if subclinical psychotic symptoms and psychotic disorders share the same neurobiology. WeExpand
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Acute induction of anxiety in humans by delta-9-tetrahydrocannabinol related to amygdalar cannabinoid-1 (CB1) receptors
Use of Cannabis, the most widely used illicit drug worldwide, is associated with acute anxiety, and anxiety disorders following regular use. The precise neural and receptor basis of these effectsExpand
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