Eugeniusz Baran

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CTLA-4 molecule is an important inhibitor of T-lymphocyte activation. Several single nucleotide polymorphisms (SNPs) in the CTLA-4 gene were found, and their associations with many human diseases were described. So far, however, such studies have not been performed in psoriasis vulgaris in Caucasoids. Therefore, we examined the distribution of three CTLA-4(More)
Overexpression of IL-6 has been implicated in the pathology of numerous autoimmune and chronic inflammatory diseases, including psoriasis, and relative deficiency of IL-10 in psoriatic patients seems to be important in the development of this disease. The aim of this study was to investigate the association between IL-6 and IL-10 single nucleotide(More)
OBJECTIVE To evaluate the prevalence and factors influencing the presence of concomitant dermatomycoses in patients with toenail onychomycosis. DESIGN Prospective study based on a specially designed questionnaire completed by dermatologists. PATIENTS A total of 2761 patients with toenail onychomycosis. MAIN OUTCOME MEASURES The diagnosis of fungal(More)
Association of psoriasis vulgaris with HLA-C is not equally strong in different human populations. It has not yet been studied in Polish patients at DNA level, but only by serology that is inadequate for HLA-C. Therefore, we examined the distribution of HLA-C alleles by means of low resolution PCR-SSP in 102 Polish psoriatics and 123 healthy controls. We(More)
Hydatid disease is endemic in many regions of Turkey. We observed 23 cases of simultaneous liver hydatid cyst in 344 patients having pulmonary hydatid cyst referred to our center. The simultaneous hydatid cysts were diagnosed by ultrasonography. In all cases complete resection was possible in a single operation. We performed thoracophrenotomy in 21 cases(More)
Cadmium, zinc and copper levels were determined in the renal cortex and liver of 60 inhabitants of Cracow, Poland. Cadmium levels in the renal cortex were contained in broad limits of 5-176 μg/g, mean 50.6 μg/g (wet weight). Maximum levels were found in the age group of about 50-60 years. The levels were slightly higher in men (53 μg/g) than in women (45(More)
BACKGROUND Genes encoded within the MHC complex on chromosome 6 are thought to play an important role in the pathogenesis of psoriasis. A potential candidate is tumor necrosis factor alpha (TNF-alpha) gene. Psoriasis features an increased activity of the proinflammatory cytokine TNF-alpha in affected lesions. TNF-alpha promoter region contains several(More)
Histone deacetylase inhibitor romidepsin has demonstrated durable clinical responses and tolerability in patients with relapsed/refractory peripheral and cutaneous T-cell lymphoma (PTCL, CTCL). Selection of novel drug therapies for patients with relapsed/refractory aggressive lymphoma requires not only considerations regarding efficacy but also careful(More)
BACKGROUND In patients with systemic scleroderma (SSc), clinically evident cardiac involvement is recognized to be a poor prognostic factor. The aim of the study was to evaluate electrocardiographic changes, parameters of heart rate variability (HRV), and heart rate turbulence (HRT) in patients with SSc without evident symptoms of heart disease. METHODS A(More)