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Cubical Shape Enhances the Interaction of Layer-by-Layer Polymeric Particles with Breast Cancer Cells.
Blood-borne objects display a nonspherical shape with in-flow dimensions much larger than the vascular endothelial fenestrations, yet, at the diseased state, are able to traverse through theseExpand
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Ultrathin polymeric coatings based on hydrogen-bonded polyphenol for protection of pancreatic islet cells.
Though transplantation of pancreatic islet cells has emerged as a promising treatment for Type 1 diabetes its clinical application remains limited due to a number of limitations including bothExpand
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Internalization of Red Blood Cell-Mimicking Hydrogel Capsules with pH-Triggered Shape Responses
We report on naturally inspired hydrogel capsules with pH-induced transitions from discoids to oblate ellipsoids and their interactions with cells. We integrate characteristics of erythrocytes suchExpand
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Hydrogen-bonded multilayers of tannic acid as mediators of T-cell immunity.
Type 1 diabetes is an autoimmune-mediated disease resulting in the destruction of insulin-secreting pancreatic β-cells. Transplantation of insulin-producing islets is a viable treatment to restoreExpand
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Resolution Agonist 15-epi-Lipoxin A4 Programs Early Activation of Resolving Phase in Post-Myocardial Infarction Healing
Following myocardial infarction (MI), overactive inflammation remodels the left ventricle (LV) leading to heart failure coinciding with reduced levels of 15-epi-Lipoxin A4 (15-epi LXA4). However, theExpand
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Intracellular Degradable Hydrogel Cubes and Spheres for Anti-Cancer Drug Delivery.
Shape and responsiveness of nanoengineered delivery carriers are crucial characteristics for rapid and efficient delivery of therapeutics. We report on a novel type of micrometer-sized hydrogelExpand
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Encapsulation and Surface Engineering of Pancreatic Islets: Advances and Challenges
Type 1 diabetes (T1D) is a chronic autoimmune disease representing a major health care problem worldwide (Tierney et al., 2002). T1D is caused by islet-reactive immune T cells that destroyExpand
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Multilayer Hydrogel Capsules of Interpenetrated Network for Encapsulation of Small Molecules.
We report on a facile capsule-based platform for efficient encapsulation of a broad spectrum of hydrophilic compounds with molecular weight less than 1000 g mol-1. The encapsulated compounds extendExpand
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Temperature-responsive polymersomes of poly(3-methy-N-vinylcaprolactam)-block-(poly(N-vinylpyrrolidone) to decrease doxorubicin-induced cardiotoxicity.
Despite being one of the most potent chemotherapeutics, doxorubicin (DOX) facilitates cardiac toxicity by irreversibly damaging the cardiac muscle as well as severely dysregulating the immune systemExpand
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Biocompatible shaped particles from dried multilayer polymer capsules.
We demonstrated a simple and facile approach to fabricate biocompatible monodisperse hollow microparticles of controlled geometry. The hemispherical, spherical, and cubical microparticles areExpand
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