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  • Raymond Evers, Shannon Dallas, +7 authors Lei Zhang
  • Biology, Medicine
  • Drug metabolism and disposition: the biological…
  • 1 September 2013
  • Drug-drug interactions (DDIs) between therapeutic proteins (TPs) and small-molecule drugs have recently drawn the attention of regulatory agencies, the pharmaceutical industry, and academia. TP-DDIsContinue Reading
  • Kenneth T Luu, Simon Bergqvist, En-Hong Chen, Dana Hu-Lowe, Eugenia A Kraynov
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 June 2012
  • In the drug discovery and development setting, the ability to accurately predict the human pharmacokinetics (PK) of a candidate compound from preclinical data is critical for informing the effectiveContinue Reading
  • Kenna L. Anderes, David R. Luthin, +11 authors John M. May
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 May 2003
  • Gonadotropin-releasing hormone (GnRH) receptor antagonists have potential in treating numerous hormone-dependent pathologies including cancers of the prostate, breast, and ovary, endometriosis, andContinue Reading