Eugeni Domènech

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Despite the availability of biological drugs and the widespread and earlier use of immunosuppressants, intestinal resection remains necessary in almost half of the patients with Crohn's disease. Th e development of new mucosal lesions in previously unaff ected intestinal segments (a phenomenon known as post-operative recurrence, POR) occur within the fi rst(More)
BACKGROUND Immune-mediated inflammatory diseases (IMIDs) are a group of complex and prevalent diseases where disease diagnostic and activity monitoring is highly challenging. The determination of the metabolite profiles of biological samples is becoming a powerful approach to identify new biomarkers of clinical utility. In order to identify new metabolite(More)
  • Violeta Lorén, Eduard Cabré, Isabel Ojanguren, Eugeni Domènech, Elisabet Pedrosa, Arce García-Jaraquemada +3 others
  • 2015
Glucocorticosteroids are the first line therapy for moderate-severe flare-ups of ulcerative colitis. Despite that, up to 60% of patients do not respond adequately to steroid treatment. Previously, we reported that low IL-10 mRNA levels in intestine are associated with a poor response to glucocorticoids in active Crohn's disease. Here, we test whether IL-10(More)
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