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In this paper we describe data exploration techniques designed to classify DNA sequences. Several visualization and data mining techniques were used to validate and attempt to discover new methods for distinguishing coding DNA sequences, or exons, from non-coding DNA sequences, or introns. The goal of the data mining was to see whether some other possibly(More)
We investigate the relation between trading activity—measured by the number of trades N t —and the price change G t for a given stock over a time interval [t, t + t]. We relate the time-dependent standard deviation of price changes—volatility—to two microscopic quantities: the number of transactions N t in t and the variance W 2 t of the price changes for(More)
Using molecular dynamics simulations, we study a spherically symmetric 'two-scale' Jagla potential with both repulsive and attractive ramps. This potential displays a liquid–liquid phase transition with a positively sloped coexistence line ending at a critical point well above the equilibrium melting line. We study the dynamic behaviour in the vicinity of(More)
Detailed results are reported for the connectivity properties of a system of discs of unit radius free to be situated anywhere within a square of area 2L2. Ordinary lattke percolation would correspond to the discs being situated on the vertices of a J2L x J 2 L lattice. Computer simulations are carried out for a sequence of increasing system sizes ranging(More)
Experimental evidence suggests that the folding and aggregation of the amyloid ␤-protein (A␤) into oligomers is a key pathogenetic event in Alzheimer's disease. Inhibiting the pathologic folding and oligomerization of A␤ could be effective in the prevention and treatment of Alzheimer's disease. Here, using all-atom molecular dynamics simulations in explicit(More)
Water can be supercooled to temperatures as low as −92 • C, the experimental crystal homogeneous nucleation temperature T H at 2 kbar. Within the supercooled liquid phase its response functions show an anomalous increase consistent with the presence of a liquid–liquid critical point located in a region inaccessible to experiments on bulk water. Recent(More)
Water is characterized by a density anomaly whose origin is a matter of debate. Theoretical works have shown that two of the proposed explanations, the second-critical-point hypothesis and the singularity-free scenario, have the same microscopic origin, but arise from different choices of parameters, such as the hydrogen bond strength or geometry. We(More)
Water's behavior differs from that of normal fluids, having more than sixty anomalies. Simulations and theories propose that many of these anomalies result from the coexistence of two liquid phases with different densities. Experiments in bulk water confirm the existence of two local arrangements of water molecules with different densities, but, because of(More)