Eugene Ozhinsky

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BACKGROUND Previous studies of the patellofemoral joint have been limited by the use of invasive techniques, measurements under non-weight-bearing conditions, cadaveric specimens, or computerized models. It has been shown that soft tissue and bone can be accurately quantified with magnetic resonance imaging. The present study was designed to define the(More)
PURPOSE To quantify normal, in vivo tibio-femoral knee joint kinematics in multiple weight bearing positions using non-invasive, high-resolution MRI and discuss the potential of developing future kinematic methods to assess patients with abnormal joint pathologies. METHODS Ten volunteers with clinically normal knees pushed inferiorly on the footplate of a(More)
Micro-finite element (FE) analysis is a well established technique for the evaluation of the elastic properties of trabecular bone, but is limited in its application due to the large number of elements that it requires to represent the complex internal structure of the bone. In this paper, we present an alternative FE approach that makes use of a recently(More)
Consistent scan prescription for MRI of the knee is very important for accurate comparison of images in a longitudinal study. However, consistent scan region selection is difficult due to the complexity of the knee joint. We propose a novel method for registering knee images using a mutual information registration algorithm to align images in a baseline and(More)
PURPOSE To compare the precision and accuracy of 3.0-T and 1.5-T magnetic resonance (MR) imaging in the quantification of cartilage volume by using direct volumetric measurements as a reference standard. MATERIALS AND METHODS The local animal experimentation committee did not require its approval for this study. Porcine knees were obtained from an(More)
PURPOSE To demonstrate the feasibility of using ultrashort echo-time MRI to quantify T1 changes in cortical bone due to heating. METHODS Variable flip-angle T1 mapping combined with 3D ultrashort echo-time imaging was used to measure T1 in cortical bone. A calibration experiment was performed to detect T1 changes with temperature in ex vivo cortical bone(More)
BACKGROUND Near-field heating is a potential problem in focused ultrasound treatments, as it can result in thermal injury to skin, subcutaneous fat, and other tissues. Our goals were to determine if T2-based temperature mapping could be used reliably to measure near-field heating in adipose tissue and whether it is practical to perform such mapping during(More)
BACKGROUND Current clinical protocols for MR-guided focused ultrasound (MRgFUS) treatment of osseous lesions, including painful bone metastases and osteoid osteomas, rely on measurement of the temperature change in adjacent muscle to estimate the temperature of the bone. The goal of this study was to determine if T2-based thermometry could be used to(More)
Background/introduction This study presents the implementation of protracted mild hyperthermia (HT) delivery to large contiguous volumes in prostate quadrants or hemi-gland targets by utilizing a commercially available MR-guided endorectal ultrasound (ERUS) phased array designed for thermal ablation (ExAblate 2100, InSightec. Ltd). HT-specific beamforming,(More)
Background/introduction MR-guided high-intensity focused ultrasound (HIFU) for treatment of uterine fibroids and painful bone metastases uses the proton resonant frequency shift (PRF) for temperature monitoring in water-based tissues. However, PRF fails to detect temperature changes in tissues with high lipid content, such as fat and bone marrow. Previous(More)