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A remarkable feature of peripheral olfactory projections in mammals is the convergence of axons from olfactory sensory neurons (OSNs) expressing the same odorant receptor (OR) into the same glomeruli. There is mounting evidence that the ORs play critical roles in glomerular formation. However, it remains unclear how the OR exerts its function of sorting(More)
PURPOSE We assessed the efficacy and safety of the tyrosine kinase inhibitor sunitinib in Korean patients with metastatic renal cell carcinoma (mRCC). MATERIALS AND METHODS Between September 2007 and December 2009, all twenty-one patients who had mRCC with a clear-cell component were retrospectively reviewed. Sunitinib was administered orally at a dose of(More)
This paper presents an RF MEMS resonator with embedded junction field effect transistor (JFET) for efficient electrical detection of the high quality factor acoustic resonance. A homogenous single-crystal silicon resonator is excited in its fundamental thickness extensional resonant mode at 1.61 GHz with a quality factor of 25,900. This device can be fully(More)
This paper presents a micromachined lead zirconate titanate-on-silicon electromechanical resonator, tunable from series to parallel resonance, for either bandstop or bandpass filter applications. Scattering parameter measurements (9.2 V direct current (DC) bias) reveal bandstop rejection levels > 109 dB at 59.74 MHz and passband loss of 40 dB with a À20-dB(More)
This paper reports on the experimental verification of the intrinsic loss mechanisms present in degenerately doped single-crystal silicon. Previous work reported at the Hilton Head Workshop 2010 [1] experimentally showed the dominant acoustic loss mechanism in a 3.72-GHz silicon resonator (Fig. 1) to be Landau-Rumer phonon-phonon dissipation as seen from(More)
—This paper presents a supplement to the theory of internal dielectric transduction presented in [1] by including the effects of acoustic mismatch on the resonant frequency and motional impedance of internal dielectrically transduced micromechanical resonators. Analytical expressions for the mode shapes in said resonators are mathematically derived and(More)
Investigating therapeutic "outliers" that show exceptional responses to anti-cancer treatment can uncover biomarkers of drug sensitivity. We performed preclinical trials investigating primary murine acute myeloid leukemias (AMLs) generated by retroviral insertional mutagenesis in KrasG12D "knockin" mice with the MEK inhibitor PD0325901 (PD901). One outlier(More)
—We present in this paper the design and fabrication of a homogeneous silicon micromechanical resonator actuated using forces acting on the immobile charge in the depletion region of a symmetrically doped p-n diode. The proposed resonator combines the high quality factor Q of air-gap-transduced res-onators with the frequency-scaling benefits of internal(More)
—This work presents a novel cascaded filter array architecture for large-scale MEMS filter arrays that overcomes the limitations associated with the large shunt capacitance to efficiently scale the number of filters in the array. The proposed architecture effectively reduces the capacitive loading at the input by utilizing a series connection of the(More)