Eugene J. Pietzak
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Next-generation Sequencing of Nonmuscle Invasive Bladder Cancer Reveals Potential Biomarkers and Rational Therapeutic Targets.
BACKGROUND Molecular characterization of nonmuscle invasive bladder cancer (NMIBC) may provide a biologic rationale for treatment response and novel therapeutic strategies. OBJECTIVE To identify… Expand
Genetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors.
- Aditya Bagrodia, Byron K. H. Lee, +27 authors D. Feldman
- Journal of clinical oncology : official journal…
- 19 September 2016
Purpose Owing to its exquisite chemotherapy sensitivity, most patients with metastatic germ cell tumors (GCTs) are cured with cisplatin-based chemotherapy. However, up to 30% of patients with… Expand
Genomic Differences Between "Primary" and "Secondary" Muscle-invasive Bladder Cancer as a Basis for Disparate Outcomes to Cisplatin-based Neoadjuvant Chemotherapy.
BACKGROUND Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) is the standard of care for patients with muscle-invasive bladder cancer (MIBC). It is unknown whether… Expand
Clonal Relatedness and Mutational Differences between Upper Tract and Bladder Urothelial Carcinoma
- F. Audenet, Sumit Isharwal, +20 authors D. Solit
- Biology, Medicine
- Clinical Cancer Research
- 23 October 2018
Purpose: To investigate genomic differences between urothelial carcinomas of the upper tract (UTUC) and bladder (UCB), with a focus on defining the clonal relatedness of temporally distinct tumors.… Expand
Impact of race on selecting appropriate patients for active surveillance with seemingly low-risk prostate cancer.
- Eugene J. Pietzak, K. V. Van Arsdalen, K. Patel, S. Malkowicz, A. Wein, T. Guzzo
- 1 February 2015
OBJECTIVE To evaluate active surveillance (AS) criteria on their ability to predict favorable pathology at prostatectomy within a low-risk African American (AA) cohort. METHODS The sensitivity,… Expand
Outcomes of radical cystectomy in potential candidates for bladder preservation therapy.
OBJECTIVE To analyze the outcomes of patients with urothelial-type bladder cancer (UBC) who optimally met selection criteria for bladder preservation therapy (BPT) but were treated with radical… Expand
Genomic landscape of inverted urothelial papilloma and urothelial papilloma of the bladder
- Sumit Isharwal, Wenhuo Hu, +15 authors H. Al-Ahmadie
- Medicine, Biology
- The Journal of pathology
- 1 July 2019
Inverted urothelial papilloma (IUP) and urothelial papilloma (UP) are rare urothelial neoplasms that typically follow a benign clinical course. Oncogenic mutations in FGFR3, HRAS, and the TERT… Expand
The Impact of Blue Light Cystoscopy on the Diagnosis and Treatment of Bladder Cancer
- Eugene J. Pietzak
- Current Urology Reports
- 21 March 2017
Photodynamic diagnostic technique with blue light cystoscopy (BLC) takes advantage of the preferential uptake and accumulation of protoporphyrins in neoplastic tissue which emit a red fluorescence… Expand
Histology of Testicular Biopsies Obtained for Experimental Fertility Preservation Protocol in Boys with Cancer.
PURPOSE Cryopreservation of testicular tissue with subsequent reimplantation after therapy has the potential to preserve fertility for prepubertal boys with cancer. We present the histology and… Expand
The Impact of Plasmacytoid Variant Histology on the Survival of Patients with Urothelial Carcinoma of Bladder after Radical Cystectomy.
BACKGROUND The clinical significance of the plasmacytoid variant (PCV) in urothelial carcinoma (UC) is currently lacking. OBJECTIVE To compare clinical outcomes of patients with any PCV with that… Expand