Eugene J. Barrett

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Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD study.

Frans J. Th. Wackers, Lawrence H. Young, +10 authors Ami E. Iskandrian
Diabetes care
2004

OBJECTIVE To assess the prevalence and clinical predictors of silent myocardial ischemia in asymptomatic patients with type 2 diabetes and to test the effectiveness of current American Diabetes… (More)

Management of hyperglycemic crises in patients with diabetes.

Abbas E. Kitabchi, Guillermo E Umpierrez, +4 authors Barry M. Wall
Diabetes care
2001

131 D iabetic ketoacidosis (DKA) and hyper-osmolar hyperglycemic state (HHS) are two of the most serious acute complications of diabetes. These hypergly-cemic emergencies continue to be important… (More)

Hemodynamic actions of insulin in rat skeletal muscle: evidence for capillary recruitment.

Stephen Rattigan, Michael S. G. Clark, Eugene J. Barrett
Diabetes
1997

Insulin-induced increases in blood flow are hypothesized to enhance overall glucose uptake by skeletal muscle. Whether the insulin-mediated changes in blood flow are associated with altered blood… (More)

Effect of physiologic hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man.

Robert A. Gelfand, Eugene J. Barrett
The Journal of clinical investigation
1987

Although insulin stimulates protein synthesis and inhibits protein breakdown in skeletal muscle in vitro, the actual contribution of these actions to its anabolic effects in man remains unknown.… (More)

Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes: the DIAD study: a randomized controlled trial.

Lawrence H. Young, Frans J. Th. Wackers, +9 authors Silvio E. Inzucchi
JAMA
2009

CONTEXT Coronary artery disease (CAD) is the major cause of mortality and morbidity in patients with type 2 diabetes. But the utility of screening patients with type 2 diabetes for asymptomatic CAD… (More)

Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin.

Michelle A. Vincent, Eugene J. Barrett, Jonathan R. Lindner, Michael S. G. Clark, Stephen Rattigan
American journal of physiology. Endocrinology and…
2003

We examined the effects of inhibiting nitric oxide synthase with Nomega-nitro-l-arginine-methyl ester (l-NAME) on total hindlimb blood flow, muscle microvascular recruitment, and hindlimb glucose… (More)

Effect of fatty acids on glucose production and utilization in man.

Ele Ferrannini, Eugene J. Barrett, Stefano Bevilacqua, Ralph A DeFronzo
The Journal of clinical investigation
1983

Since the initial proposal of the glucose fatty acid cycle, considerable controversy has arisen concerning its physiologic significance in vivo. In the present study, we examined the effect of acute,… (More)

Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo.

Michelle A. Vincent, Lucy H. Clerk, +4 authors Eugene J. Barrett
Diabetes
2004

Insulin increases glucose disposal into muscle. In addition, in vivo insulin elicits distinct nitric oxide synthase-dependent vascular responses to increase total skeletal muscle blood flow and to… (More)

Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo.

William Oliver Martin, Dennis J. Hoover, +6 authors Judith L. Treadway
Proceedings of the National Academy of Sciences…
1998

An inhibitor of human liver glycogen phosphorylase a (HLGPa) has been identified and characterized in vitro and in vivo. This substance, [R-(R*,… (More)

Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow.

Michelle A. Vincent, Dana K. Dawson, +4 authors Eugene J. Barrett
Diabetes
2002

Supraphysiological doses of insulin enhance total limb blood flow and recruit capillaries in skeletal muscle. Whether these processes change in response to physiological hyperinsulinemia is… (More)

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