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The problem of identifying complex epistatic quantitative trait loci (QTL) across the entire genome continues to be a formidable challenge for geneticists. The complexity of genome-wide epistatic analysis results mainly from the number of QTL being unknown and the number of possible epistatic effects being huge. In this article, we use a composite model(More)
Using lines of mice having undergone long-term selection for high and low growth, a large-sample (n = approximately 1,000 F2) experiment was conducted to gain further understanding of the genetic architecture of complex polygenic traits. Composite interval mapping on data from male F2 mice (n = 552) detected 50 QTL on 15 chromosomes impacting weights of(More)
The contribution that pleiotropic effects of individual loci make to covariation among traits is well understood theoretically and is becoming well documented empirically. However, little is known about the role of epistasis in determining patterns of covariation among traits. To address this problem we combine a quantitative trait locus (QTL) analysis with(More)
Non-directional variation in right minus left differences in bilateral characters, referred to as fluctuating asymmetry (FA), often has been assumed to be largely or entirely environmental in origin. FA increasingly has been used as a measure of developmental stability, and its presumed environmental origin has facilitated the comparisons of populations(More)
The concept of the genetic correlation for one trait across environments was extended to two environmental factors B and C. Three additive genetic correlations for the same trait were defined: rG, across both environmental factors; rG(B), across C and within B; and rG(C), across B and within C. As genotype x environment variances increase, the genetic(More)
A genetic framework was developed for the interpretation of statistical parameters estimated from a diallel experiment among a fixed set of lines. These included average direct genetic, average maternal genetic, general combining ability, reciprocal, and line and specific direct and maternal heterotic effects. The genetic model is based on direct and(More)
We examined the maternal behavior of hubb/hubb mutant mice and normal control (+/hubb) siblings. From previous observations we noted that mutants groom their pups less, suckle less than normal, and often cannibalize the young. To date, these observations had not been quantified. Although prolactin (PRL) is linked to maternal behavior, it was difficult to(More)
Lines of mice which have been genetically differentiated in litter size at birth and 6-week body weight by single-trait or index selection were randomly assigned to be reared in postnatal litter sizes (PLS) of N8, N12 or N16. The lines were selected as follows: large litter size (L+), large 6-week body weight (W+), selection index to decrease litter size(More)
The relative influence of litter size at birth and dam body weight at parturition on lactational performance was determined with five among-line crossfostering experiments involving 17 populations of mice. Included were lines selected for postweaning growth and maternal performance, and unselected controls. Twelve-day litter weight of a crossfostered litter(More)