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Using a reproducible screening procedure for rat liver cytochrome P450 isoenzyme induction/inhibition, five dicarbamate drugs (meprobamate, mebutamate, carisoprodol, tybamate, and W-554) were compared with sodium phenobarbital and found to be from 25 to 100 times less potent hepatic cytochrome P450 inducers than phenobarbital.
We describe a visualization application intended for operational use in formulating business strategy in the customer service arena. The visualization capability provided in this application implicitly allows the user to better formulate the objective function for large optimization runs which act to minimize costs based on certain input parameters.… (More)