Learn More
Activation of PI-PLC initiates two independent branches of protein phosphorylation cascades catalyzed by either PKC or Ca2+/calmodulin-dependent protein kinase (CaMK). We find that phosrestin I (PRI), a Drosophila homolog of vertebrate photoreceptor arrestin, undergoes light-induced phosphorylation on a subsecond time scale which is faster than that of any(More)
Light activation of rhodopsin in the Drosophila photoreceptor induces a G protein-coupled signaling cascade that results in the influx of Ca2+ into the photoreceptor cells. Immediately following light activation, phosphorylation of a photoreceptor-specific protein, phosrestin I, is detected. Strong sequence similarity to mammalian arrestin and(More)
Multifunctional Ca2+/calmodulin-dependent protein kinase type II (CaMK II) plays a crucial role in mediation of cellular responses to rising cytosolic Ca2+ levels. We find that the novel peptide substrate PGTIEKKRSNAMKKMKSIEQHR serves as a highly potent substrate for CaMK II enzymes purified from both Drosophila and rat. The peptide is derived from a(More)
Reverse transcription-polymerase chain reaction and western immunoblot analyses were performed to demonstrate the presence of beta-arrestin-1 in rat dorsal root ganglion. beta-Arrestin-1 existed as two alternatively spliced variants, although predominantly in its untruncated form. Several factors affected the visualization of the truncated version on a(More)
  • Eugen Kahn
  • 2008
In some social groups the acquisition of property is called theft. This may be a perfectly obvious proposition to those who have no property, but is not an appealing one to most of those who have acquired or have inherited property in what is or has been considered an honest way. In most societies people who possess property are generally not brought to(More)
  • Eugen Kahn
  • 2008
Two patients ailing from the same disease never present identical pictures; there is always a difference in symptomatology. This holds true for the physical symptoms of all diseases. It is no less true for the symptoms of the mental disturbances accompanying other diseases, or as we might as well say, other bodily diseases, since the psychoses, so-called,(More)
  • 1