Etsuya Watanabe

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The mechanism by which bacillus Calmette-Guérin (BCG) mediates antitumor activity has not been clearly established. Specific cytokines in the urine after BCG intravesical instillation therapy may serve as a prognostic factor of treatment response. In this study, various urinary cytokines such as interleukin-1β (IL-1β), IL-2, IL-6, IL-8. IL-10, IL-12,(More)
Administration of growth factors is emerging as a new therapeutic approach for the enhancement of collateral vessel formation in the ischemic heart. We have investigated the effects of intramyocardial delivery of FGF-2 in the presence and absence of heparin on angiogenesis in a porcine model of myocardial infarction. Yorkshire pigs were subjected to(More)
Transplantation of cardiomyocytes into the heart is a potential treatment for replacing damaged cardiac muscle. To investigate the feasibility and efficiency of this technique, either a cardiac-derived cell line (HL-1 cells), or normal fetal or neonatal pig cardiomyocytes were grafted into a porcine model of myocardial infarction. The myocardial infarction(More)
I. Fifty of the bile canaliculi located in the centrolobular area, under 20,000 of magnification, were selected from each cases of three normal, three Dubin-Johnson syndrome and three Rotor syndrome cases. And their luminal areas and number of microvilli were measured and statistically analyzed, This study indicated canalicular dilatation of mild degree(More)
This paper concerns the effects of diuretics on glutaminase-I activity of liver and kidney extracts, arginase activity and urea synthesis of liver extract and ATP production of liver mitochondria. These aspects of diuretic action have been studied rarely, but are important to be settled, especially in liver cirrhosis where ammonia plays a pathogenetic role(More)
increase of b i l i rubin in the bile was markedly delayed in compar ison wi th the increase of bile b i l i rubin of ra t s wi th non-blockade. On the e lectron microscopic observat ion of the l ivers of these rats , numerous electron dense granules, probably hemoglobin, were seen taking up to the RES cells. These findings indicate tha t most of hemoglobin(More)
The results were as follows; 1) A significant decrease in se rum zinc was found in cases of the gastric cancer. 2) Zinc concentrat ion of gastric juice tended to increase in cases of the gastric cancer as compared with the normal subjects. 3) Urinary excretion of zinc remained within the normal range in patients of the gastric cancer without any metastasis(More)
A 33 year old man, had been jaundiced since from infancy. Except for the icterus his only complaint had been that of fatigabil i ty. He was diagnosed in past as icterus ca tar rh l is , hemolytic ic terus and chronic hepati t is . His fa ther ' s g randfa ther was the brother of his mother ' s grandmother . A sister, aged 42 years, had been jaundiced since(More)
Object ; We observed with respect to bind with serum protein to I. C. G. Method ; Human serum was diluted by 0.9% solution in a wide range of concentration and then added I .C.G. solution. The optical density at 805 m/~ and 785 m/~ was plotted in each concentration. At intersection point of the both absorption curve was seen by one's Graph we calculated the(More)