Etsuroh Arai

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Previously we have found such "bizarre stereotypy" as persistent and bloody biting activity at the legs or the tail of himself or of the cage mate given methamphetamine (MAPT, 10 mg/kg) 24 hrs-48 hrs after long term-administration of reserpine (RE). The present investigation examined the effect of inhibition of dopamine synthesis in brain on MAPT-induced(More)
The present study was undertaken to determine whether or not adrenalectomy influences anesthesia and increase in brain 5-HT induced by pentobarbital and if such is the case, whether or not aldosterone or ACTH inhibit the effect of adrenalectomy. Male Wistar rats were adrenalectomized or sham-operated and injected with aldosterone (20mug5hg i.p.), ACTH (5.0(More)
Cortisone, aldosterone or nialamide was administered to adrenalectomized or sham-operated rats for 7 days, and methamphetamine was injected 24 hrs after the last injection of these compounds. Stereotyped head movement and licking activity were scored 5 min, 30 min and 60 min after methamphetamine injection and, in parallel brain methamphetamine levels in(More)
Infleunce of hyper-and hypothyroidism on amphetamine activity was observed by measuring the effects on hyperthermia and brain amphetamine and norepinephrine levels. Hyperthyroidism was obtained in rats injected with tri-iodothyronine 0.2 mg/kg i.p. every day for 5 days. Controls were treated with the vehicle 1.0 ml/kg i.p. for the same period. On the 6th(More)
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