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Côte d’Ivoire produces 40 % of the world supply of cocoa but much of the plantation area is aging and declining in productivity, while opportunities for land expansion into new forest land are quickly disappearing. Rejuvenation strategies for cocoa presently coalesce either around improved varieties and greater use of agro-chemical inputs in full sun(More)
We analyse how physicians respond to contractual changes and incentives within a multitasking environment. In 1999 the Quebec government (Canada) introduced an optional mixed compensation (MC) system, combining a fixed per diem with a partial (relative to the traditional fee-for-service (FFS) system) fee for services provided. We combine panel survey and(More)
OBJECTIVES GSK1322322 is a potent inhibitor of peptide deformylase, an essential bacterial enzyme required for protein maturation. In this two-part, double-blind, randomized, placebo-controlled, Phase 1 study (study identifier: PDF112668), the safety, tolerability and pharmacokinetics of single and repeat oral-dose GSK1322322 (500-1500 mg) in healthy adult(More)
GSK1322322 is the first in a new class of antibiotics that inhibit peptide deformylase, necessary for bacterial protein maturation. Previously, low absolute bioavailability was observed for the 1500‐mg oral tablet formulation, resulting in a less than dose‐proportional increase from the 1000‐mg dose. Furthermore, high variability of pharmacokinetic (PK)(More)
is an antibiotic in development by GlaxoSmithKline. In this study, we investigated the metabolism and disposition of [ 14 C]GSK1322322 in healthy humans and demonstrated the utility of the Entero-Test in a human radiolabel study. We successfully collected bile from five men using this easy-to-use device after single i.v. (1000 mg) or oral administration(More)
mass spectrometry; AUC (0-t) , area under the plasma versus time concentration curve from time zero to time of the measured concentration; AUC (0-∞) , area under the plasma versus time concentration curve from time zero Abstract GSK2251052 is a novel boron-containing antibiotic that inhibits bacterial leucyl tRNA synthetase (LeuRS) and that has been in(More)
Bentham's economics of emulation 3 Introduction 1 In 1825 Bentham published The Rationale of Reward 2 , a work containing the English translation by Richard Smith of Théorie des récompenses [1811], one of Bentham's works originally published in French and edited by Etienne Dumont. reveal, Bentham was working at that time to the major project of the last(More)
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