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BACKGROUND To identify new molecular markers of bone marrow dissemination in human neuroblastoma (NB), we studied the transcriptome profiles of malignant neuroblasts established from the human MYCN-amplified IGR-N-91 model. METHODS This experimental model includes human neuroblastoma cells derived from a subcutaneous stage 4 disease, myocardium (Myoc) and… (More)
Lipin-1 deficiency is associated with massive rhabdomyolysis episodes in humans, precipitated by febrile illnesses. Despite well-known roles of lipin-1 in lipid biosynthesis and transcriptional regulation, the pathogenic mechanisms leading to rhabdomyolysis remain unknown. Here we show that primary myoblasts from lipin-1-deficient patients exhibit a… (More)
We briefly describe the French Enconverter and the French Deconverter. We discuss then a few general points concerning the possibility of designing dependency trees equivalent to UNL graphs, the treatment of the ambiguity and anaphora resolution, and the structure of the compound nodes.
An interactive hypertextual environment for MT training is described. It combines the ARIANE MT system with an hypertextual control interface implemented on the learner's personal computer, and communicating with the ARIANE server through e-mail.
The mechanisms by which pollutants participate in the development of diverse pathologies are not completely understood. The pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) activates the AhR (aryl hydrocarbon receptor) signaling pathway. We previously showed that TCDD (25 nM, 30 h) decreased the expression of several alcohol metabolism enzymes… (More)