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A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources
Blood-brain barrier (BBB) models are often used to investigate BBB function and screen brain-penetrating therapeutics, but it has been difficult to construct a human model that possesses an optimalExpand
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Deterministic HOX Patterning in Human Pluripotent Stem Cell-Derived Neuroectoderm
Summary Colinear HOX expression during hindbrain and spinal cord development diversifies and assigns regional neural phenotypes to discrete rhombomeric and vertebral domains. Despite the precision ofExpand
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Defined Human Pluripotent Stem Cell Culture Enables Highly Efficient Neuroepithelium Derivation Without Small Molecule Inhibitors
The embryonic neuroepithelium gives rise to the entire central nervous system in vivo, making it an important tissue for developmental studies and a prospective cell source for regenerativeExpand
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Human Blood-Brain Barrier Endothelial Cells Derived from Pluripotent Stem Cells
The blood-brain barrier (BBB) is crucial to the health of the brain and is often compromised in neurological disease. Moreover, because of its barrier properties, this endothelial interface restrictsExpand
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Blood–brain barrier modeling with co‐cultured neural progenitor cell‐derived astrocytes and neurons
J. Neurochem. (2011) 119, 507–520.
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Evidence for a two-step mechanism in electronically selective single-walled carbon nanotube reactions.
Covalent and noncovalent chemistries that are selective to single-walled carbon nanotubes of a particular electronic type have become increasingly important for electronic structure separation andExpand
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Accelerated differentiation of human induced pluripotent stem cells to blood–brain barrier endothelial cells
BackgroundDue to their ability to limitlessly proliferate and specialize into almost any cell type, human induced pluripotent stem cells (iPSCs) offer an unprecedented opportunity to generate humanExpand
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Activation of RARα, RARγ, or RXRα Increases Barrier Tightness in Human Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells.
The blood-brain barrier (BBB) is critical to central nervous system (CNS) health. Brain microvascular endothelial cells (BMECs) are often used as in vitro BBB models for studying BBB dysfunction andExpand
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Endothelial cells are critical regulators of iron transport in a model of the human blood–brain barrier
Iron delivery to the brain is essential for multiple neurological processes such as myelination, neurotransmitter synthesis, and energy production. Loss of brain iron homeostasis is a significantExpand
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iPSC-Derived Brain Endothelium Exhibits Stable, Long-Term Barrier Function in Perfused Hydrogel Scaffolds
Summary There is a profound need for functional, biomimetic in vitro tissue constructs of the human blood-brain barrier and neurovascular unit (NVU) to model diseases and identify therapeuticExpand
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