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Borrelia burgdorferi BBB07 interaction with integrin α3β1 stimulates production of pro‐inflammatory mediators in primary human chondrocytes
Borrelia burgdorferi, the causative agent of Lyme disease, activates multiple signalling pathways leading to induction of pro‐inflammatory mediators at sites of inflammation. Binding of B.Expand
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Identification of a TLR-Independent Pathway for Borrelia burgdorferi-Induced Expression of Matrix Metalloproteinases and Inflammatory Mediators through Binding to Integrin α3β11
Borrelia burgdorferi stimulates a robust inflammatory response at sites of localization. Binding of borrelial lipoproteins to TLR-2 is one pathway important in the host response to B. burgdorferi.Expand
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Mature Black Cherry Used as a Bioindicator of Ozone Injury
Incidence and severity of foliar symptoms due to ambient ozone exposures were documented on mature black cherry (Prunus serotina) in two National Parks [Great Smoky Mountains National Park (GRSM) andExpand
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Role of aggrecanase 1 in Lyme arthritis.
OBJECTIVE Arthritis is one of the hallmarks of late-stage Lyme disease. Previous studies have shown that infection with Borrelia burgdorferi, the causative agent of Lyme disease, results inExpand
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Borrelia burgdorferi-Induced Expression of Matrix Metalloproteinases from Human Chondrocytes Requires Mitogen-Activated Protein Kinase and Janus Kinase/Signal Transducer and Activator of
ABSTRACT Elevations in matrix metalloproteinase 1 (MMP-1) and MMP-3 have been found in patients with Lyme arthritis and in in vitro models of Lyme arthritis using cartilage explants and chondrocytes.Expand
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MyD88 Deficiency Results in Tissue-Specific Changes in Cytokine Induction and Inflammation in Interleukin-18-Independent Mice Infected with Borrelia burgdorferi
ABSTRACT Toll-like receptors (TLRs) play an important role in the control of infection with Borrelia burgdorferi. Deficiencies in TLR-2 or the shared TLR adapter molecule MyD88 have been shown toExpand
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Induction of Host Matrix Metalloproteinases by Borrelia burgdorferi Differs in Human and Murine Lyme Arthritis
ABSTRACT Matrix metalloproteinases (MMPs) are induced from host tissues in response to Borrelia burgdorferi. Upregulation of MMPs may play a role in the dissemination of the organism throughExpand
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Borrelia burgdorferi BBB07 interaction with integrin alpha3beta1 stimulates production of pro-inflammatory mediators in primary human chondrocytes.
Borrelia burgdorferi, the causative agent of Lyme disease, activates multiple signalling pathways leading to induction of pro-inflammatory mediators at sites of inflammation. Binding of B.Expand
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Visible ozone injury on mature black cherry in two Class I wilderness areas
During the summer of 1991--1993, the incidence and severity of foliar symptoms due to ambient ozone exposures were documented on mature black cherry (Prunus serotina) in two Class 1 areas in theExpand