Esther von Stebut

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α derived TNF − released from neutrophils recruited by mast cell β / α dependent on MIP-1 Early macrophage influx to sites of cutaneous granuloma formation is Updated information and services can be found at: (973 articles) Phagocytes (4939 articles) Immunobiology (564 articles) Chemokines, Cytokines, and Interleukins Articles on similar topics can be found(More)
Leishmaniasis is one of the most important infectious diseases worldwide; a vaccine is still not available. Infected dendritic cells (DC) are critical for the initiation of protective Th1 immunity against Leishmania major. Phagocytosis of L. major by DC leads to cell activation, IL-12 release and (cross-) presentation of Leishmania antigens by DC. Here, we(More)
Intradermal administration of antigen-encoding RNA has entered clinical testing for cancer vaccination. However, insight into the underlying mechanism of RNA uptake, translation and antigen presentation is still limited. Utilizing pharmacologically optimized naked RNA, the dose–response kinetics revealed a rise in reporter signal with increasing RNA amounts(More)
Leishmaniasis is a parasitic infection affecting ,12 million people worldwide, mostly in developing countries. Treatment options are limited and no effective vaccines exist to date. Natural Killer T (NKT) cells are a conserved innate-like lymphocyte population with immunomodulating effects in various settings. A number of reports state a role of NKT cells(More)
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