Esther von Stebut

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Learn More Updated information and services can be found at: (973 articles) Phagocytes • (4939 articles) Immunobiology • (564 articles) Chemokines, Cytokines, and Interleukins • Articles on similar topics can be found in the following Blood collections(More)
Most parasitic skin infections are averted by very efficient strategies of preventing pathogen invasion. Innate immune cells such as mast cells, macrophages and dendritic cells are responsible for detecting parasites and for recruiting proinflammatory cells that help to contain and control the pathogen at sites of infection. This induces efficient adaptive(More)
Leishmaniasis is one of the most important infectious diseases worldwide; a vaccine is still not available. Infected dendritic cells (DC) are critical for the initiation of protective Th1 immunity against Leishmania major. Phagocytosis of L. major by DC leads to cell activation, IL-12 release and (cross-) presentation of Leishmania antigens by DC. Here, we(More)
Autoimmunerkrankungen können klinisch unter dem Bild einer therapierefraktären chronischen Urtikaria (CU) auftreten. Der vorliegende Fall schildert den Verlauf bei einem Patienten mit hypokomplementämischem Urtikaria-Vaskulitis-Syndrom (HUVS) und den schnellen Behandlungserfolg mit hoch dosierten intravenösen Immunglobulinen (IVIG). Die Diagnose wurde(More)
Modulation of protein kinase C (PKC) activity in basophils (B) can influence IgE-mediated histamine release (HR). The present study investigated the effects of chelerythrine, which inhibits isolated PKC (IC50 0.7 μM), on different activation pathways in B. FcεRI-mediated HR was strongly inhibited by chelerythrine (86.5±5.4%, 5 μM,n=11). TPA-induced mediator(More)
Intradermal administration of antigen-encoding RNA has entered clinical testing for cancer vaccination. However, insight into the underlying mechanism of RNA uptake, translation and antigen presentation is still limited. Utilizing pharmacologically optimized naked RNA, the dose–response kinetics revealed a rise in reporter signal with increasing RNA amounts(More)
Leishmaniasis is a parasitic infection affecting ,12 million people worldwide, mostly in developing countries. Treatment options are limited and no effective vaccines exist to date. Natural Killer T (NKT) cells are a conserved innate-like lymphocyte population with immunomodulating effects in various settings. A number of reports state a role of NKT cells(More)
Arachidonic acid metabolites generated from activated basophils and/or mast cells mediate different types of cutaneous inflammatory reactions. To clarify the mechanisms of leukotriene C4 (LTC4) production from human basophils, cells were purified from the peripheral blood by negative selection with immunobeads. The protein kinase C (PKC) activators(More)
In the present study the effects of different activators of protein kinase C (PKC) on histamine release from human basophils were studied. The phorbol esters 12-O-tetradecanoyl-phorbol-13-acetate (TPA), phorbol-12,13-dibutyrate (PDBu), phorbol-12,13-didecanoate, and the non-phorbol mezerein induced a dose-dependent mediator release, whereas(More)