Esther del Olmo

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MOTIVATION Although natural products represent a reservoir of molecular diversity, the process of isolating and identifying active compounds is a bottleneck in drug discovery programs. The rapid isolation and identification of the bioactive component(s) of natural product mixtures during the bioassay-guided fractionation have become crucial factors in the(More)
Twenty compounds selected as representative members of three series of long-chain 1,2-diamines, 2-amino-1-alkanols and 1-amino-2-alkanols structurally related to dihydrosphingosin, were synthesized and tested in vitro for their ability to inhibit the sleeping sickness parasites Trypanosoma bruceirhodesiense and Trypanosoma brucei gambiense. Eight compounds(More)
BACKGROUND AND AIMS Tuberculosis (TB) is a major worldwide health problem in part due to the lack of new drugs and the emergence of multidrug-resistant strains (MDR). The aim of this study was to select anti-tuberculosis drug candidates from a collection of 69 synthetic sphingosine-ethambutol analogues through in vitro and in vivo evaluations. METHODS The(More)
Hypertension is one of the most common cardiovascular diseases, leading to the development of stroke, coronary heart disease, cardiac failure or renal insufficiency [1]. Consequently, much work is ongoing with the aim of developing novel and more efficacious antihypertensive drugs. Drugs which increase vascular relaxation through different mechanisms are a(More)
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