Esther S Bochmann

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The feasibility of predicting melt rheology by using the glass transition temperature (Tg) of a desired amorphous solid dispersion (ASD) for hot-melt extrusion (HME) and other melt based processes is presented. Three groups of three different active pharmaceutical ingredients (APIs) or plasticizer/copovidone mixtures, with identical glass transition in(More)
Most of current approaches in designing and implementing distributed multimedia (MM) presentational applications, e.g. news-on-demand, have concentrated on the performance of the continuous media file servers in terms of seek time overhead, and real-time disk scheduling; particularly the QoS negotiation mechanisms they provide are used in a rather static(More)
A new predictive micro-scale solubility and process model for amorphous solid dispersions (ASDs) by hot-melt extrusion (HME) is presented. It is based on DSC measurements consisting of an annealing step and a subsequent analysis of the glass transition temperature (Tg). The application of a complex mathematical model (BCKV-equation) to describe the(More)
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