Esther M.M. van Lieshout

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Alternative splicing of primary transcripts from the calcitonin/α calcitonin gene-related peptide (αCGRP) gene result in mature mRNAs encoding either calcitonin or αCGRP. We have produced sequence-specific, synthetic, biotinylated oligodeoxynucleotide probes that recognize calcitonin (exon 4), and αCGRP (exon 6) sequences as well as sequences common to both(More)
Background. Infectious complications remain a serious threat to polytraumatized patients. Susceptibility and response to infection is, in part, heritable. The lectin pathway plays a major role in innate immunity. The aim of this study was to assess if single nucleotide polymorphisms (SNPs) in three key genes within the lectin pathway affect susceptibility(More)
The purpose of this study was to identify risk factors for the development of infection after open fracture fixation. A comprehensive search in all scientific literature of the last 30 years was performed in order to identify patient-, trauma-, diagnosis- and treatment-related risk factors. Studies were included when infectious complications were assessed(More)
Trauma is a major public health problem worldwide. Infectious complications, sepsis, and multiple organ dysfunction syndrome (MODS) remain important causes for morbidity and mortality in patients who survive the initial trauma. There is increasing evidence for the role of genetic variation in the innate immune system on infectious complications in severe(More)
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