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We report a case of a 66-yr-old woman with progressive hair balding, hirsutism and virilization. Gonadotropins and estradiol levels were in the postmenopausal range; total testosterone (TT), free testosterone (FT) and 17-hydroxyprogesterone (17-OHP) were elevated with dehydroepiandrosterone sulphate, androstendione and cortisol serum levels in the normal(More)
Several studies in vitro and in vivo suggest that the nitric oxide (NO) production is impaired in diabetes mellitus. Reduced levels of NO could contribute to vascular alteration facilitating platelet-vascular wall interaction, adhesion of monocytes to endothelium, vascular smooth muscle proliferation and by decreasing endothelium-dependent vasodilation. In(More)
Several studies suggest that nitric oxide (NO) production is impaired in diabetes mellitus. Reduced levels of NO could contribute to cardiovascular mortality. Furthermore, NO synthesis is impaired in glutathione (GSH)-depleted human umbilical vein endothelial cells and GSH is reduced in patients with type 2 diabetes mellitus (T2DM). We tested the hypothesis(More)
The growing availability of information on the Web has raised a challenging problem: can a Web-based information system tailor itself to different user requirements with the ultimate goal of personalizing and improving the users' experience in accessing the contents of a website? This paper proposes a new approach to website personalization based on the(More)
This paper introduces active integrity constraints (AICs), an extension of integrity constraints for consistent database maintenance. An active integrity constraint is a special constraint whose body contains a conjunction of literals which must be false and whose head contains a disjunction of update actions representing actions (insertions and deletions(More)