Ester Mengual

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Thalamocortical neurons innervating the barrel cortex in neonatal rodents transiently store serotonin (5-HT) in synaptic vesicles by expressing the plasma membrane serotonin transporter (5-HTT) and the vesicular monoamine transporter (VMAT2). 5-HTT knock-out (ko) mice reveal a nearly complete absence of 5-HT in the cerebral cortex by immunohistochemistry,(More)
The striatal return through the thalamus is largely neglected in current studies dealing with basal ganglia function, and its role within this circuitry remains obscure. In this contribution the thalamus is regarded as an important place of interaction between the input and the output organization of the basal ganglia. In support of this idea, a brief(More)
The proteasome multicatalytic proteinase (MCP) is a 20S complex that plays a major role in nonlysosomal pathways of intracellular protein degradation. A polyclonal antibody against rat liver MCP was used to investigate the distribution of MCP in the CNS of the rat and its subcellular localization within the neurons. As expected, MCP immunoreactivity(More)
Fluorescent tracers were injected into different regions of the caudate nucleus and HRP-WGA in the substantia nigra of the cat in order to analyse the thalamic distribution of retrogradely labelled thalamostriatal neurones and anterogradely labelled nigrothalamic terminals within the thalamus. Overlapping thalamic territories between the thalamostriatal(More)
Several cortico-cortical and limbic-related circuits are enriched in zinc, which is considered as an important modulator of glutamatergic transmission. While heavy metals have been detected in the thalamus, the specific presence of zinc has not been examined in this region. We have used two highly sensitive variations of the Timm method to study the(More)
The distribution of vesicular or chelatable zinc was analysed in the dorsal and ventral subdivisions of the striatum and globus pallidus of the rat with Danscher's selenium method. Acetylcholinesterase and Calbindin-D28k were used as striatal and pallidal markers in order to analyse the possible compartmentalization of the distribution of zinc in the(More)
The distribution of thalamic neurons projecting directly to the caudate nucleus (CN) was examined using the retrograde labeling method. Horseradish peroxidase conjugated with wheat germ agglutinin (HRP-WGA) or a fluorescent tracer (either Fast Blue (FB) or Diamidino Yellow (DY)) was injected into various parts of the CN. The main findings were as follows:(More)
The distribution of thalamostriatal neurons projecting to the cat caudate nucleus was examined by retrograde fluorescent tracers. Thus, Fast Blue and Diamidino Yellow were concomitantly injected in different rostrocaudal, dorsoventral, or mediolateral sectors of the caudate nucleus. The main findings of this study are as follows: (1) few double-labeled(More)
Patches of high nicotinamide-adenine dinucleotide phosphate diaphorase (NADPH-d) activity were found in the mediodorsal and midline thalamic nuclei of cats. These patches matched acetylcholinesterase (AChE)-rich patches within the medial thalamus, whereas other AChE-rich patches were NADPH-d negative. There were also patches of NADPH-d activity in the(More)