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Amputees can move their phantom limb at will. These 'movements without movements' have generally been considered as motor imagery rather than motor execution, but amputees can in fact perform both executed and imagined movements with their phantom and they report distinct perceptions during each task. Behavioural evidence for this dual ability comes from(More)
Amputees who have a phantom limb often report the ability to move this phantom voluntarily. In the literature, phantom limb movements are generally considered to reflect motor imagery rather than motor execution. The aim of this study was to investigate whether amputees distinguish between executing a movement of the phantom limb and imagining moving the(More)
Motor representations express some degree of somatotopy in human primary motor hand area (M1HAND), but within-M1HAND corticomotor somatotopy has been difficult to study with transcranial magnetic stimulation (TMS). Here we introduce a "linear" TMS mapping approach based on the individual shape of the central sulcus to obtain mediolateral corticomotor(More)
A substantial body of evidence documents massive reorganization of primary sensory and motor cortices following hand amputation, the extent of which is correlated with phantom limb pain. Many therapies for phantom limb pain are based upon the idea that plastic changes after amputation are maladaptive and attempt to normalize representations of cortical(More)
PURPOSE OF REVIEW Noninvasive brain stimulation (NIBS) is increasingly used to enhance the recovery of function after stroke. The purpose of this review is to highlight and discuss some unresolved questions that need to be addressed to better understand and exploit the potential of NIBS as a therapeutic tool. RECENT FINDINGS Recent meta-analyses showed(More)
There is evidence showing that white matter changes are clinically relevant and can be associated with cognitive disorders, slower mental processing speed or motor impairment. The complex structural organization of the white matter can be depicted in vivo in great detail with advanced diffusion-weighted imaging (DWI). From the simplest and most commonly(More)
Noninvasive transcranial brain stimulation (NTBS) is widely used to elucidate the contribution of different brain regions to various cognitive functions. Here we present three modeling approaches that are informed by functional or structural brain mapping or behavior profiling and discuss how these approaches advance the scientific potential of NTBS as an(More)
BACKGROUND AND AIM Clinicians need a simple method for quantifying gait activity. The aim of this study was to develop and validate the reliability of a quantitative gait assessment based exclusively on one magnetometer located on the shank. METHODS Twenty-five healthy volunteers were simultaneously equipped with a magnetometer (MAG system) on the right(More)
BACKGROUND The resting motor threshold (RMT) is used to individually adjust the intensity of transcranial magnetic stimulation (TMS) intensity and is assumed to be stable. Here we challenge this notion by showing that RMT expresses acute context-dependent fluctuations. METHOD In twelve participants, the RMT of the right first dorsal interosseus muscle was(More)
Using the short-latency afferent inhibition (SAI) paradigm, transcranial magnetic stimulation (TMS) of the primary motor hand area (M1HAND) can probe how sensory input from limbs modulates corticomotor output in humans. Here we applied a novel TMS mapping approach to chart the spatial representation of SAI in human hand-knob. We hypothesized SAI is(More)
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