Estelle Marchand

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Lung volume reduction surgery has become an accepted therapeutic option to relieve the symptoms of selected patients with severe emphysema. In a majority of these patients, it causes objective as well as subjective functional improvement. A proper understanding of the physiological determinants underlying these beneficial effects appears very important in(More)
A deterministic method for sensitivity analysis is developed and applied to a mathematical model for the simulation of flow in porous media. The method is based on the singular value decomposition (SVD) of the Jacobian matrix of the model. It is a local approach to sensitivity analysis providing a hierarchical classification of the directions in both the(More)
UNLABELLED The authors have demonstrated previously that emphysema and lung volume reduction surgery (LVRS) resulted in a significant shift of type IIx/b to type IIa fibres in the diaphragm of hamsters with elastase-induced emphysema. To explore the mechanisms leading to this fibre switching, the mRNA expression of the myogenic regulatory factors, the(More)
In Western countries, allergic broncho-pulmonary aspergillosis (ABPA) in childhood is very unusual beyond the context of cystic fibrosis (CF). It is presumed to be different in adulthood, although three studies 1e3 reported an increased frequency of cystic fibrosis transmembrane conductance regulator (CFTR) mutations in adults with ABPA. Out of the 63(More)
Lung volume reduction surgery (LVRS) has been shown to improve respiratory mechanics in selected patients with severe emphysema. This is thought to be due to an improvement in lung elastic recoil. This study was aimed at gaining further understanding about the effects of LVRS on respiratory mechanics and airway function. Control hamsters instilled with(More)
Naturally in your positions, you are interested in the use of words, as should be your authors and must be your readers. Here are three examples. SIGNIFICANT This has been with us for decades. It is sometimes accompanied by statistical probability values in parentheses. It literally means ''full of meaning or import'' [1]. Used alone it means the authors(More)
questionnaire [3] assessment in the treated subjects, also showed a positive impact of one of the most important end-points of the long-term ventilatory strategy in these patients, which is the health-related quality of life (HRQoL). Although, it is still not clear whether survival can be positively influenced by NPPV in addition to standard long-term(More)
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