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  • Anna Biela-Banaś, Farah Oulaïdi, +5 authors Olivier R. Martin
  • Chemistry, Medicine
  • ChemMedChem
  • 2014 (First Published: 1 December 2014)
  • Several families of iminosugar-based galactoside mimics were designed, synthesized, and evaluated as galactocerebrosidase (GALC) inhibitors. They were also tested as inhibitors of lysosomal β- andContinue Reading
  • Wojciech Schönemann, Estelle Gallienne, +7 authors Olivier R. Martin
  • Chemistry, Medicine
  • ChemMedChem
  • 2013 (First Published: 1 November 2013)
  • A series of iminoxylitol derivatives carrying a C-linked di-O-acyl or di-O-alkyl glyceryl substituent were prepared and characterized. All of these compounds, which were designed as glucosylceramideContinue Reading
  • Sophie Front, Anna Biela-Banaś, +8 authors Olivier R. Martin
  • Chemistry, Medicine
  • European journal of medicinal chemistry
  • 2017
  • This report is about the identification, synthesis and initial biological characterization of derivatives of 4-epi-isofagomine as pharmacological chaperones (PC) for human lysosomal β-galactosidase.Continue Reading
  • Sophie Front, Sofia S. Almeida, +8 authors Stéphane Demotz
  • Medicine, Chemistry
  • Bioorganic & medicinal chemistry
  • 2018 (First Published: 1 November 2018)
  • (5aR)-5a-C-pentyl-4-epi-isofagomine 1 is a powerful inhibitor of lysosomal β-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B. WeContinue Reading
  • Wojciech Schönemann, Estelle Gallienne, Philippe Compain, Kyoko Ikeda, Naoki Asano, Olivier R. Martin
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry
  • 2010 (First Published: 1 April 2010)
  • A short synthesis of new beta-1-C-alkyl-1,5-dideoxy-1,5-imino-l-iditols by means of the diastereoselective addition of Grignard reagents onto a glucopyranosylamine is described. These compounds wereContinue Reading