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BACKGROUND Beginning with Kraepelin, schizophrenia has been viewed as a progressive disorder. Although numerous studies of the longitudinal course of schizophrenia have demonstrated the clinical deterioration that occurs predominantly in the early stages of the illness, the pathophysiology of this clinical phenomenon has not been established. This aspect of(More)
OBJECTIVE The authors conducted a review and meta-analysis of studies that compared the efficacy and tolerability of typical and second-generation antipsychotics for patients with treatment-resistant schizophrenia. METHOD A systematic search revealed 12 controlled studies (involving 1,916 independent patients), which were included in the review. For the(More)
The size of the necrotic lesion may be a significant factor in predicting outcome and determining treatment in hips with avascular necrosis. However, to date most reports on the treatment of this condition have not attempted to correlate outcome with lesion size. Seventy-three hips with avascular necrosis were evaluated, 11 in Stage I and 62 in Stage II.(More)
During the insertion of an automatic implantable cardioverter defibrillator, repeated induction of ventricular tachycardia or ventricular fibrillation and subsequent defibrillation is performed to determine the defibrillation threshold. In this study, the influence of these testing episodes on myocardial function was investigated in 13 patients under(More)
The aims of this study were to determine whether infants and toddlers with chronic lung disease of infancy (CLDI) have smaller airways and lower lung density compared with full-term healthy controls. Multi-slice computed tomography (CT) chest scans were obtained at elevated lung volumes during a brief respiratory pause in sedated infants and toddlers; 38(More)
Renal involvement in systemic sclerosis (SSc) has a negative influence on prognosis. Cases of SSc sine scleroderma have been reported in which organ failure occurred but was not accompanied by cutaneous damage, which in some instances did develop later. We describe a patient who, after 6 months of symmetric polyarthritis, developed rapid progressive renal(More)
These are two cases of cocaine abuse with the following previously unreported cocaine-associated features: 1) biopsy-proven accelerated/malignant hypertension, 2) association of cocaine with persistent hypertension, and 3) renal failure with rapid progression to end-stage renal disease that did not reverse following blood pressure control.