Essam M Abdelalim

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BNP signaling is crucial for embryonic stem cell proliferation

BACKGROUND Embryonic stem (ES) cells have unlimited proliferation potential, and can differentiate into several cell types, which represent ideal sources for cell-based therapy. This high-level… (More)

Expression and Localization of Mitochondrial Ferritin mRNA in Alzheimer's Disease Cerebral Cortex

Ligang Wang, Hongkuan Yang, +6 authors Ikuo Tooyama
PloS one
2011

Mitochondrial ferritin (MtF) has been identified as a novel ferritin encoded by an intron-lacking gene with specific mitochondrial localization located on chromosome 5q23.1. MtF has been associated… (More)

NPR-A regulates self-renewal and pluripotency of embryonic stem cells

Essam M Abdelalim, Ikuo Tooyama
Cell Death and Disease
2011

Self-renewal and pluripotency of embryonic stem (ES) cells are maintained by several signaling cascades and by expression of intrinsic factors, such as Oct4, Nanog and Sox2. The mechanism regulating… (More)

Molecular Mechanisms Controlling the Cell Cycle in Embryonic Stem Cells

Essam M Abdelalim
Stem Cell Reviews and Reports
2013

Embryonic stem (ES) cells are originated from the inner cell mass of a blastocyst stage embryo. They can proliferate indefinitely, maintain an undifferentiated state (self-renewal), and differentiate… (More)

Knockdown of p53 suppresses Nanog expression in embryonic stem cells.

Essam M Abdelalim, Ikuo Tooyama
Biochemical and biophysical research…
2014

Mouse embryonic stem cells (ESCs) express high levels of cytoplasmic p53. Exposure of mouse ESCs to DNA damage leads to activation of p53, inducing Nanog suppression. In contrast to earlier studies,… (More)

Advances and challenges in the differentiation of pluripotent stem cells into pancreatic β cells.

Essam M Abdelalim, Mohamed Moheeb Emara
World journal of stem cells
2015

Pluripotent stem cells (PSCs) are able to differentiate into several cell types, including pancreatic β cells. Differentiation of pancreatic β cells depends on certain transcription factors, which… (More)

Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1

Bushra Memon, Manale Karam, Sara Al-Khawaga, Essam M Abdelalim
Stem Cell Research & Therapy
2017

Pancreatic progenitors (PPs) co-expressing the two transcription factors (TFs) PDX1 and NKX6.1 are recognized as the indispensable precursors of functional pancreatic β cells. Here, we aimed to… (More)

Neuropathy of type 1 diabetes in the Arab world: A systematic review and meta-analysis.

Ussama M Abdel-Motal, Essam M Abdelalim, Haissam Abou-Saleh, Hatem Zayed
Diabetes research and clinical practice
2017

AIMS Although type 1 diabetes (T1D) is a common disease in the Arab nations, there is no data available on the prevalence of peripheral neuropathy (PN) among T1D subjects in Arab countries. The aim… (More)

Expression of NPR-B in neurons of the dorsal root ganglia of the rat

Essam M Abdelalim, Jean-Pierre Bellier, Ikuo Tooyama
Peptides
2013

C-type natriuretic peptide (CNP) is an abundant neuropeptide in the central nervous system, which exerts its physiological effects through natriuretic peptide receptor B (NPR-B). Recently, the… (More)

Pluripotent Stem Cells as a Potential Tool for Disease Modelling and Cell Therapy in Diabetes

Essam M Abdelalim, Amélie Bonnefond, Annelise Bennaceur-Griscelli, Philippe Froguel
Stem Cell Reviews and Reports
2014

Diabetes mellitus is the most prevailing disease with progressive incidence worldwide. To date, the pathogenesis of diabetes is far to be understood, and there is no permanent treatment available for… (More)

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