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Recurrent vulvovaginal candidiasis (RVVC) is defined as having four or more symptomatic vulvovaginal candidiasis (VVC) attacks within a year. This study aimed to investigate whether Human Dectin-1 Y238X Gene Polymorphism plays a role in RVVC pathogenesis. In order to examine and explore this aim, an experimental study was undergone. The clinical study(More)
Chronic myeloproliferative disorders such as polycythemia vera (PV), essential thrombocytosis (ET), and idiopathic myelofibrosis arise from clonal proliferation of neoplastic stem cells in the bone marrow. Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that have potential to degrade all types of extracellular matrix (ECM) and(More)
PURPOSE Pelvic organ prolapse is a multifactorial disorder in which extracellular matrix defects are implicated. Fibrillin-1 level is reduced in stress urinary incontinence. In Marfan syndrome, which is associated with mutations in Fibrillin-1, pelvic floor disorders are commonly observed. We hypothesize that Fibrillin-1 gene expression is altered in pelvic(More)
Tumor masses are composed of heterogenic subpopulations of cancer cells, and cancer stem cell theory suggests that only a specific subpopulation of these cells has the ability to sustain cancer growth and metastatic activity, whereas all of the other cancer cells have only a limited growth potential or no growth potential at all. Based on this concept in(More)
The basic principle of bone induction for tissue engineering is to use stem cells, growth factors and organic matrix. KUSA/A1 cell is an example of bone marrow stromal stem cell, capable of differentiating into osteoblasts, chondrocytes and myotubes under inducing conditions. It has been reported that mature KUSA/A1 osteoblasts cultured in osteogenic(More)
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