Esper Abrão Cavalheiro

Maria da Graça Naffah-Mazzacoratti24
Carla Alessandra Scorza14
Sérgio Gomes da Silva13
24Maria da Graça Naffah-Mazzacoratti
14Carla Alessandra Scorza
13Sérgio Gomes da Silva
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SUMMARY Although ATP and P2X receptor activity have been lately associated with epilepsy, little is known regarding their exact roles in epileptogenesis. Temporal-lobe epilepsy (TLE) in rat was induced by pilocarpine in order to study changes of hippocampal P2X(2), P2X(4) and P2X(7) receptor expression during acute, latent or chronic phases of epilepsy.(More)
  • Sérgio Gomes da Silva, Nicolas Unsain, Daniel Hugo Mascó, Michelle Toscano-Silva, Henrique Alves de Amorim, Bruno Henrique Silva Araújo +6 others
  • 2012
There is a great deal of evidence showing the capacity of physical exercise to enhance cognitive function, reduce anxiety and depression, and protect the brain against neurodegenerative disorders. Although the effects of exercise are well documented in the mature brain, the influence of exercise in the developing brain has been poorly explored. Therefore,(More)
To investigate whether the type of physical activity, voluntary or forced, would promote different morphological changes in hippocampal formation we performed an immunocytochemical study using the parvalbumin (PV) distribution as a marker. Animals submitted to the voluntary exercise were placed in a voluntary wheel running and those submitted to the forced(More)
Exercise stimulates the release of beta-endorphin and other endogenous opioid peptides that are believed to be responsible for changes in mood, perception of pain and also performance. Although the vast majority of literature data support the role of physical exercise in increasing beta-endorphin levels, indirect measures such as increased endorphin levels(More)
In order to investigate whether physical exercise during development would promote changes the calcium-binding protein parvalbumin (PV) expression in the hippocampal formation, we performed an immunostaining study after an aerobic exercise program in rats during adolescent period of life. Wistar rats were submitted to daily exercise program in a treadmill(More)
Aging is often accompanied by cognitive decline, memory impairment and an increased susceptibility to neurodegenerative disorders. Most of these age-related alterations have been associated with deleterious processes such as changes in the expression of inflammatory cytokines. Indeed, higher levels of pro-inflammatory cytokines and lower levels of(More)
Exposure to different physical and cognitive stimulus have been shown to induce extensive neuronal plasticity in both undamaged and injured central nervous system, such as enhanced neurogenesis in the dentate gyrus of the hippocampus, up-regulation of neurotrophic factors and improved learning and memory. Neuronal plasticity also is found during certain(More)
  • Sandra Regina Perosa, Gustavo Adolfo Argañaraz, Eduardo Massatoshi Goto, Luciana Gilbert Pessoa Costa, Ana Carla Konno, Pedro Paulo Vasconcellos Varella +10 others
  • 2007
Molecular biology tools have been employed to investigate the participation of peptides in human temporal lobe epilepsy (TLE). Active polypeptides and their receptors have been related to several brain processes, such as inflammation, apoptosis, brain development, K(+) and Ca(2+) channels' activation, cellular growth, and induction of neuronal(More)
  • João Ananias Machado-Filho, Alyne Oliveira Correia, Anyssa Brilhante Aires Montenegro, Maria Elizabeth Pereira Nobre, Gilberto Santos Cerqueira, Kelly Rose Tavares Neves +4 others
  • 2014
Several lines of evidences have shown the inversion association between coffee consumption and Parkinson's disease (PD) development. Caffeine is a methylxanthine known as a non-selective inhibitor of A2A and A1 adenosine receptors in the brain and shown to be a neuroprotective drug. The objectives were to study caffeine effects in a unilateral 6-OHDA model(More)
  • Giovany Michely Pinto da Cruz, Cícero Francisco Bezerra Felipe, Fúlvio Alexandre Scorza, Marta Aline Coelho da Costa, Alinne Farias Tavares, Maria Luiza Feitosa Menezes +6 others
  • 2013
Piperine, an alkaloid present in the Piper genus, was shown to have an anticonvulsant activity, evaluated by the pilocarpine-induced model, in mice. Pilocarpine (350mg/kg, i.p.) was administered 30min after piperine (2.5, 5, 10 and 20mg/kg, i.p.) which significantly increased latencies to 1st convulsion and to death, and percentage of survivals. These(More)