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- Luiz E. A. M. Mello, Esper Abrão Cavalheiro, +4 authors Deborah M. Finch
- Epilepsia
- 1993
We used the pilocarpine model of chronic spontaneous recurrent seizures to evaluate the time course of supragranular dentate sprouting and to assess the relation between several changes that occur in… (More)
- Waldemar Andrzej Turski, Esper Abrão Cavalheiro, Michael Schwarz, Stanisław Jerzy Czuczwar, Zdzisław Kleinrok, Lechoslaw Turski
- Behavioural Brain Research
- 1983
Behavioural, electroencephalographic and neuropathological responses to increasing doses of pilocarpine (100-400 mg/kg) administered intraperitoneally to rats were studied. At the dose of 400 mg/kg… (More)
High-dose treatment with pilocarpine hydrochloride, a cholinergic muscarinic agonist, induces seizures in rodents following systemic or intracerebral administration. Pilocarpine seizures are… (More)
Structural damage of the human brain (perinatal damage, cerebral trauma, head injury, cerebrovascular and degenerative diseases, intracranial tumor, metabolic diseases, toxins, drug-induced seizures)… (More)
- Waldemar Andrzej Turski, Esper Abrão Cavalheiro, Zuner Assis Bortolotto, Luiz E. A. M. Mello, Lechosław Turski
- Brain Research
- 1984
Increasing doses of pilocarpine, 100-400 mg/kg, were given intraperitoneally to mice and the resulting behavioral, electroencephalographic and neuropathological alterations were studied. No… (More)
- Esper Abrão Cavalheiro
- The Italian Journal of Neurological Sciences
- 1995
The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioural and electrographic changes that can be divided in three distinct periods: (a) an acute… (More)
- Joao Pereira Leite, Zuner Assis Bortolotto, Esper Abrão Cavalheiro
- Neuroscience & Biobehavioral Reviews
- 1990
Seizures induced by pilocarpine (PILO) have proven to be a useful procedure for investigating the basic mechanisms essential for generation, spread and motor expression of seizures in rodents. Here… (More)
- Esper Abrão Cavalheiro, Neide dos Santos, Margareth Rose Priel
- Epilepsia
- 1996
PURPOSE
To characterize the acute and chronic behavioral, electrographic and histologic effects of sustained seizures induced by pilocarpine in mice.
METHODS
After status epilepticus, the surviving… (More)
- Margareth Rose Priel, Neusa Fernandes dos Santos, Esper Abrão Cavalheiro
- Epilepsy Research
- 1996
Prolonged seizures in young children may precede the later development of focal or generalized seizures. To study the age-related susceptibility to the development of chronic epilepsy we used the… (More)
Behavioral, electroencephalographic and morphological changes induced by systemic administration of pilocarpine hydrochloride were studied in 3-90-day-old rats. Pilocarpine, 100, 200 and 380 mg/kg,… (More)