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- Thomas J Scriba, Michele Tameris, +21 authors Hassan Mahomed
- American journal of respiratory and critical care…
- 2012

RATIONALE
Novel tuberculosis (TB) vaccines should be safe and effective in populations infected with Mycobacterium tuberculosis (M.tb) and/or HIV for effective TB control.
OBJECTIVE
To determine the safety and immunogenicity of MVA85A, a novel TB vaccine, among M.tb- and/or HIV-infected persons in a setting where TB and HIV are endemic.
METHODS
An… (More)

- Cheryl L Day, Deborah A Abrahams, +9 authors Willem A Hanekom
- Journal of immunology
- 2011

High Ag load in chronic viral infections has been associated with impairment of Ag-specific T cell responses; however, the relationship between Ag load in chronic Mycobacterium tuberculosis infection and functional capacity of M. tuberculosis-specific T cells in humans is not clear. We compared M. tuberculosis-specific T cell-associated cytokine production… (More)

- Andreia Soares, Lerisa Govender, +11 authors Willem A. Hanekom
- Journal of immunological methods
- 2010

Antigen-specific proliferation is a critical function of memory T cells that is often utilised to measure vaccine immunogenicity and T cell function. We proposed that measurement of intracellular expression of the nuclear protein, Ki67, could reliably assess specific T cell proliferation in vitro. Ki67 was expressed in CD4+ and CD8+ T cells that had… (More)

Directed paths have been used extensively in the scientific literature as a model of a linear polymer. Such paths models in particular the conformational entropy of a linear polymer and the effects it has on the free energy. These directed models are simplified versions of the self-avoiding walk, but they do nevertheless give insight into the phase… (More)

A result of Milnor 1] states that the innmum of the total curvature of a tame knot K is given by 2(K), where (K) is the crookedness of the knot K. It is also known that (K)=b(K), where b(K) is the bridge index of K 2]. The situation appears to be quite diierent for knots realised as polygons in the cubic lattice. We study the total curvature of lattice… (More)

Lattice animals with fugacities conjugate to the number of cycles, or conjugate to the number of nearest neighbour contacts, go through a collapse transition at a-point at a critical value of the fugacity. We examine the phase diagram of a model which includes both a cycle-and a contact-fugacity with Monte Carlo methods. Using an underlying cut-and-paste… (More)

- E J Janse van Rensburg, A Rechnitzer
- Physical review. E, Statistical, nonlinear, and…
- 2003

The number of lattice bond trees in the square lattice (counted modulo translations), t(n), is a basic quantity in lattice statistical mechanical models of branched polymers. This number is believed to have asymptotic behavior given by t(n) approximately Alambda(n)n(-theta), where A is an amplitude, lambda is the growth constant, and theta the entropic… (More)

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