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Antigen-specific proliferation is a critical function of memory T cells that is often utilised to measure vaccine immunogenicity and T cell function. We proposed that measurement of intracellular expression of the nuclear protein, Ki67, could reliably assess specific T cell proliferation in vitro. Ki67 was expressed in CD4+ and CD8+ T cells that had… (More)

Directed paths have been used extensively in the scientific literature as a model of a linear polymer. Such paths models in particular the conformational entropy of a linear polymer and the effects it has on the free energy. These directed models are simplified versions of the self-avoiding walk, but they do nevertheless give insight into the phase… (More)

A result of Milnor 1] states that the innmum of the total curvature of a tame knot K is given by 2(K), where (K) is the crookedness of the knot K. It is also known that (K)=b(K), where b(K) is the bridge index of K 2]. The situation appears to be quite diierent for knots realised as polygons in the cubic lattice. We study the total curvature of lattice… (More)

Lattice animals with fugacities conjugate to the number of cycles, or conjugate to the number of nearest neighbour contacts, go through a collapse transition at a-point at a critical value of the fugacity. We examine the phase diagram of a model which includes both a cycle-and a contact-fugacity with Monte Carlo methods. Using an underlying cut-and-paste… (More)

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