Esma Ucisik-Akkaya

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HLA complex-linked heat shock protein genes and childhood acute lymphoblastic leukemia susceptibility

Esma Ucisik-Akkaya, Charronne F. Davis, Clara Gorodezky, Carmen Aláez, M. Tevfik Dorak
Cell Stress and Chaperones
2009

Three heat shock protein 70 (HSP70) genes, HSPA1L, HSPA1A, and HSPA1B, are located within the human leukocyte antigen (HLA) class III region. HSPs act as stress signals and regulate natural killer… (More)

Respirometric evaluation and modeling of glucose utilization by Escherichia coli under aerobic and mesophilic cultivation conditions.

Güçlü Insel, Gamze Çelikyilmaz, +4 authors Derin Orhon
Biotechnology and bioengineering
2007

The study presents a mechanistic model for the evaluation of glucose utilization by Escherichia coli under aerobic and mesophilic growth conditions. In the first step, the experimental data was… (More)

TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymphoblastic leukemia susceptibility.

Thuy Do, Esma Ucisik-Akkaya, Charronne F. Davis, Brittany A Morrison, M. Tevfik Dorak
Cancer genetics and cytogenetics
2009

Genomic and immunologic surveillance mechanisms are crucial in protection from cancer. The tumor suppressor protein p53, encoded by TP53, is a major regulator of genome surveillance. Among the… (More)

An intronic polymorphism of IRF4 gene influences gene transcription in vitro and shows a risk association with childhood acute lymphoblastic leukemia in males.

Thuy Do, Esma Ucisik-Akkaya, Charronne F. Davis, Brittany A Morrison, M. Tevfik Dorak
Biochimica et biophysica acta
2010

The interferon regulatory factor (IRF) family of DNA-binding proteins regulates expression of interferon-inducible genes with roles in the immune response and carcinogenesis. IRF4 is involved in the… (More)

Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection.

Esma Ucisik-Akkaya, Charronne F. Davis, +4 authors M. Tevfik Dorak
Molecular human reproduction
2010

Success rate in human pregnancies is believed to be very low and sex-specific mechanisms may operate in prenatal loss. Assuming a sex-differential in prenatal loss exists, we examined genetic markers… (More)

Genetic markers of pigmentation are novel risk loci for uveal melanoma

Robert Ferguson, Matjaž Vogelsang, +12 authors Tomas Kirchhoff
Scientific reports
2016

While the role of genetic risk factors in the etiology of uveal melanoma (UM) has been strongly suggested, the genetic susceptibility to UM is currently vastly unexplored. Due to shared… (More)

A study of natural killer cell lectin-like receptor K1 gene (KLRK1/NKG2D) region polymorphisms in a European population sample.

Esma Ucisik-Akkaya, M T Dorak
Tissue antigens
2009

Recent evidence has reinforced the belief in immunosurveillance as a powerful mechanism against cancer development. The natural killer (NK) cell has been recognized as a potent agent of cancer… (More)

Multiple sclerosis risk markers in HLA-DRA, HLA-C, and IFNG genes are associated with sex-specific childhood leukemia risk.

Brittany A Morrison, Esma Ucisik-Akkaya, Hilario Flores, Carmen Aláez, Clara Gorodezky, M. Tevfik Dorak
Autoimmunity
2010

Previous epidemiologic studies showed four times increased risk of acute lymphoblastic leukemia (ALL) in children of women with multiple sclerosis (MS). MS shows a risk association with Human… (More)

A Genome-Wide Screen for Sporulation-Defective Mutants in Schizosaccharomyces pombe

Esma Ucisik-Akkaya, Janet K. Leatherwood, Aaron M Neiman
G3
2014

Yeast sporulation is a highly regulated developmental program by which diploid cells generate haploid gametes, termed spores. To better define the genetic pathways regulating sporulation, a… (More)

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