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The in vivo expression of fibronectin, type I collagen, and several non-collagenous proteins was correlated with the development of bone in fetal and early neonatal rat calvariae. Fibronectin was the earliest matrix protein expressed in calvariae, with a peak expression in fetal 16- and 17-day (d) bones. Fibronectin expression coincided with the… (More)
Since osteoblast proliferation is critical for bone development, the effect of bone extracellular matrix (ECM) proteins on osteoblast signaling and proliferation in serum-free medium was investigated. Proliferation was highest in primary rat calvarial osteoblasts cells grown on fibronectin but less on type I collagen; osteonectin and poly-L-lysine did not… (More)
The intracellular signaling pathway for osteoblast adhesion to the orthopedic implant material Ti6Al4V (TIV) was investigated and compared to integrin-mediated adhesion to extracellular matrix proteins. Primary osteoblasts from fetal rat calvaria were plated onto TIV, fibronectin (FN), and poly-L-lysine (PLL) and the levels of focal adhesion kinase (FAK),… (More)
** Update 13 July ** This paper is now closed for comments. Thank you to everyone who has taken the time to leave comments. The Europeana & DPLA Working Group are reviewing the comments and will be incorporating them in the next version of the white papers. We will be providing further updates via our blogs.
This document is part of the deliverables created by the International Rights Statement Working Group, a joint working group of the Digital Public Library of America (DPLA) and Europeana. It provides the technical requirements for implementation of the Standardized International Rights Statements. These requirements are based on the principles and… (More)