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Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite.
The gut hormone ghrelin targets the brain to promote food intake and adiposity. The ghrelin receptor growth hormone secretagogue 1 receptor (GHSR) is present in hypothalamic centers controllingExpand
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UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals
This corrects the article DOI: 10.1038/nature07181
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UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals
The gut-derived hormone ghrelin exerts its effect on the brain by regulating neuronal activity. Ghrelin-induced feeding behaviour is controlled by arcuate nucleus neurons that co-express neuropeptideExpand
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Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake
The neural pathways through which central serotonergic systems regulate food intake and body weight remain to be fully elucidated. We report that serotonin, via action at serotonin1B receptorsExpand
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Agouti-related peptide–expressing neurons are mandatory for feeding
Multiple hormones controlling energy homeostasis regulate the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP) in the arcuate nucleus of the hypothalamus. Nevertheless,Expand
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Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity
The neuronal circuits involved in the regulation of feeding behavior and energy expenditure are soft-wired, reflecting the relative activity of the postsynaptic neuronal system, including theExpand
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Interaction between the Corticotropin-Releasing Factor System and Hypocretins (Orexins): A Novel Circuit Mediating Stress Response
The hypothalamic neuropeptides hypocretins (orexins) play a crucial role in the stability of arousal and alertness. We tested whether the hypocretinergic system is a critical component of the stressExpand
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Agrp Neurons Mediate Sirt1's Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity
Sirt1 has been associated with various effects of calorie restriction, including an increase in lifespan. Here we show in mice that a central regulatory component in energy metabolism, theExpand
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CPG2 A brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors
Long-term maintenance and modification of synaptic strength involve the turnover of neurotransmitter receptors. Glutamate receptors are constitutively and acutely internalized, presumptively throughExpand
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Early-Life Experience Reduces Excitation to Stress-Responsive Hypothalamic Neurons and Reprograms the Expression of Corticotropin-Releasing Hormone
Increased sensory input from maternal care attenuates neuroendocrine and behavioral responses to stress long term and results in a lifelong phenotype of resilience to depression and improvedExpand
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