Erwin T. Jacob

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Thirty cases of anorectal melanoma have been recorded in Israel from 1960 to 1981. The frequency of the disease doubled in the last decade (from 10 to 20 cases). A clear predominance has been noted among Jews of European descent (18 patients) as opposed to Sephardic Jews (9 patients) or Arabs (3 patients). From this series, the emerging conclusion is that(More)
Hemangiosarcoma of the spleen is a rare entity with only 58 reported cases. It is a highly malignant tumor and, in 80% of the cases, metastases are already present at the time of diagnosis. Thirty percent of the patients present with spontaneous rupture of the spleen. This event is catastrophic and results in rapid dissemination of the disease,(More)
Acute, ischemic renal failure was induced in rats by clamping of the renal vessels for 1 h. Following the termination of the ischemic period 5 g/kg of dimethyl sulfoxide (DMSO) were administered intravenously as a 20% solution in saline. Control animals received normal saline. There were not deaths among the DMSO-treated animals. Urine flow began within 15(More)
Ten patients with familial Mediterranean fever (FMF) and histologically confirmed amyloidosis received cadaver kidney transplants for treatment of terminal renal disease. Colchicine, 1 mg daily, was included in the routine postoperative regimen from 1974 for amyloidotic patients. Graft and patient survival were compared with ten nonamyloidotic recipients of(More)
Cimetidine, an H2 receptor antagonist, has gained acceptance as a drug capable of preventing gastroduodenal complications in renal transplant recipients. In several reports, cimetidine's immunoregulatory role has been questioned and its possible interference with graft acceptance has been observed. Two kidney allograft recipients are reported here, in whom(More)