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The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1
Abnormal accumulation of triglycerides in the liver, caused in part by increased de novo lipogenesis, results in non-alcoholic fatty liver disease and insulin resistance. Sterol regulatoryExpand
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Pestalotheols A-D, bioactive metabolites from the plant endophytic fungus Pestalotiopsis theae.
Pestalotheols A-D ( 1- 4 ), four new metabolites, have been isolated from cultures of an isolate of the plant endophytic fungus Pestalotiopsis theae. The structures of these compounds were determinedExpand
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OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin.
  • Erwei Li, H. Shan, +10 authors Yiguo Wang
  • Chemistry, Medicine
  • Cell metabolism
  • 6 August 2019
Asprosin is a fasting-induced hormone that promotes glucose production in the liver and stimulates appetite in the hypothalamus by activating the cAMP signaling pathway via an unknown GExpand
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Pestalachlorides A-C, antifungal metabolites from the plant endophytic fungus Pestalotiopsis adusta.
Pestalachlorides A-C (1-3), three new chlorinated benzophenone derivatives, have been isolated from cultures of an isolate of the plant endophytic fungus Pestalotiopsis adusta. The structures ofExpand
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PARP and RIP 1 are required for autophagy induced by 11'-deoxyverticillin A, which precedes caspase-dependent apoptosis
The epipolythiodioxopiperazines (ETPs) are fungal secondary metabolites proven to trigger both apoptotic and necrotic cell death of tumor cells. However, the underlying mechanism of their regulatoryExpand
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Genetic basis for coordination of meiosis and sexual structure maturation in Cryptococcus neoformans
In the human fungal pathogen Cryptococcus neoformans, sex can benefit its pathogenicity through production of meiospores, which are believed to offer both physical and meiosis-created lineageExpand
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A new species of Trichoderma hypoxylon harbours abundant secondary metabolites
Some species of Trichoderma are fungicolous on fungi and have been extensively studied and commercialized as biocontrol agents. Multigene analyses coupled with morphology, resulted in the discoveryExpand
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Silencing of lncRNA UCA1 curbs proliferation and accelerates apoptosis by repressing SIRT1 signals by targeting miR‐204 in pediatric AML
The long noncoding RNA urothelial carcinoma‐associated 1 (UCA1) has been reported to sustain the proliferation of acute myeloid leukemia (AML) cells through downregulating cell cycle regulatorsExpand
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Uncovering the mysterious identity of Taisui—an old Chinese folk legend
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