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In a model-driven development context (MDE), model transformations allow memorizing and reusing design know-how, and thus automate parts of the design and refinement steps of a software development process. A model transformation program is a specific program, in the sense it manipulates models as main parameters. Each model must be an instance of a(More)
The biguanides have been shown to reduce insulin requirements in type I (insulin-dependent) diabetic patients with an increase in insulin binding to insulin receptors. The aim of this was to measure the effect of metformin (850 mg/twice daily) on insulin sensitivity. Ten type I diabetic patients of normal weight received metformin or placebo in addition to(More)
[Context and motivation] Ever-growing systems' complexity and novel requirements engineering approaches such as reuse or globalization imply that requirements are produced by different stake-holders and written in possibly different languages. [Question/ prob-lem] In this context, checking consistency so that requirements specifications are amenable to(More)
Requirements documentation is a collection of partial specifications produced by different stakeholders. Obtaining a global specification is a fundamental step of a requirement analysis process. Merging requirement specifications is indeed a way to reveal inconsistencies between them. We propose in this paper a model-driven mechanism for that purpose. It(More)
The diagnosis of insulinoma on the basis of persistent hypoglycemia requires further confirmation. The insulin suppression test has been used to support this diagnosis prior to surgical intervention. In this study the euglycemic clamp technique was used to compare five control volunteers with four hypoglycemic patients with suspected insulinoma. Insulin was(More)
Ten insulin dependent diabetic patients were maintained in normoglycaemia for 36 h with an artificial pancreas. Circulating polymorphonuclear leucocytes were extracted and incubated with staphylococcus before and after treatment; phagocytic and bactericidal activities were studied. Granulocytes from diabetic patients showed a decreased ability to absorb(More)
Over a 24-month period, 274 patients with community-acquired pneumonia were hospitalized in Departments of Medicine at hospitals in Bordeaux, Lyon, Marseille, and Toulouse. Etiology of the pneumonia was determined either by organism identification or by indirect immunofluorescence in only 139 cases (51%). The most frequently isolated etiological agents were(More)
Requirements documentation is a collection of partial specifications produced by different stakeholders. Obtaining a global specification is a fundamental step of a requirement analysis process. Merging requirement specifications is indeed a way to reveal inconsistencies between them. We propose in this paper a model-driven mechanism for that purpose. It(More)
From 1972 to 1982, 22 patients were admitted for prosthetic valve endocarditis on homografts (3), bioprostheses (2) or mechanical prostheses (17). Staphylococcus epidermidis was the most common aetiologic agent in early-onset endocarditis and streptococci in late-onset. Echo-cardiographic or cinefluoroscopic findings enhanced diagnosis mainly in advanced(More)