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Parkinson's disease (PD) is a neurodegenerative disorder for which genetic susceptibility has been documented in sporadic and familial cases. Recently, a polymorphism located in exon 3 at codon 18 (S18Y) of the Ubiquitin Carboxy-terminal Hydrolase-L1 (UCH-L1) gene has been associated with the disease in 2 populations of German origin and also in a Japanese(More)
Some studies have demonstrated that the motor symptomatology in sporadic and familial Parkinson's disease was identical. From a physiopathological point of view, and perhaps in the future from a therapeutic point of view, it seems important to determine whether sporadic and familial Parkinson's disease are also similar with regard to cognitive impairment.(More)
We analyzed the segregation of genetic markers spanning chromosomal regions 2p13, 4p14-15, 4q21-23, 6q25-27, and 17q21 in nine French families affected by autosomal-dominant probable Parkinson's disease. These regions have been linked or associated with familial Parkinson's disease. Multipoint linkage and haplotype analyses excluded 2p13 and 4p14-15 loci in(More)
We present 11 families consistent with autosomal dominant inheritance of probable Parkinson's disease (PD). Although excluded as a cause of disease in these kindreds, mutations in the alpha-synuclein gene have been implicated in familial PD. The beta-synuclein gene is highly homologous, expressed in the nervous system and thus is a good candidate gene for(More)
The goal of the project in this paper is to gain experience on QoS (Quality of Service) based distributed system for EDF's power control applications. EDF is the French power utility. QoS is related to time constraints in our case. We adopted a distributed system approach to build our execution platform. The first prototype uses a modified ChorusOS(More)
The work in this paper is a case study. This paper describes how we are provisioning QoS in a real-time distributed object platform able to support power plant control applications. A previous experiment with a modified Java-ChorusOS-ATM platform based on RM-ODP/ReTINA binding objects enhanced our knowledge on QoS based distributed object systems.(More)
Since 1994, we have designed and prototyped several industrial messaging services over different platforms. Our experiments have been based on ISO-MMS standard and TASE.2. This paper describes the lessons learned from these past projects, and some of our activities in designing a next generation of industrial messaging services. Faced with a fast changing(More)
alpha-Synuclein is present in Lewy bodies of patients with both sporadic and familial Parkinson's disease. However, pathogenic mutations Ala30Pro and Ala53Thr in alpha-synuclein are rare causes of disease. Synphilin-1 has been demonstrated to associate with alpha-synuclein and promote the formation of cytosolic inclusions in vitro. Two-point genetic linkage(More)