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The firing pattern of the neurons of the internal Globus Pallidus (GPi) is greatly disturbed in Parkinson's disease. Surgical lesion or high frequency stimulation (HFS) of the GPi reduces(More)
The concept of a threshold of dopamine (DA) depletion for onset of Parkinson's disease symptoms, although widely accepted, has, to date, not been determined experimentally in nonhuman primates in(More)
High-frequency stimulation (HFS) of the subthalamic nucleus (STN) has been shown to produce a dramatic alleviation of motor symptoms in patients with advanced Parkinson's disease. Its functional(More)