Ernstgeorg Hanssen

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A central issue in the understanding of Marfan syndrome deals with the functional architecture of fibrillin-containing microfibrils. Fibrillin-rich microfibrils are long extracellular matrix fibrillar components exhibiting a 50 nm periodic beaded-structure with a width of around 20-25 nm after rotary shadowing and a 10-12 nm diameter when observed in(More)
ing s ignals : 9.6, 8.4 (broad; I H each; 8 a n d t 0 O H ; disappea r on deu te ra t ion) , 7.12 (S, l H , H 7 ) , 5 .2--5 .5 (broad, 31-I, OH p ro t ons a t 3, 4 and CH2OH ), 4.9 (d, l H ; J = t0 c/s; H l l t r an s coupled wi th H 1 2 ) and 3.8d (S, 3H, OCHa). The ace t a t e shows (CDCla) five a c e t o x y m e t h y l p ro tons a t 2.033 (S, 3H) , 2.04(More)
Ageing is marked by ultrastructural and functional changes in most tissues. In part, these changes are caused by a loss of elasticity in the elastic fibers of the extracellular matrix. These fibers are composed of the protein elastin associated with microfibrils of 8 to 12 nm in diameter. Microfibrils contain fibrillins as major constituents. Mutations in(More)
A method is described for the purification of collagen VI microfibrils and fibrillin-containing microfibrils, respectively. High M(r) microfibril-rich preparations isolated from nuchal ligament by bacterial collagenase digestion and size fractionation were purified by CsCl density gradient centrifugation. Localization of collagen VI and fibrillin within the(More)
Zonular fibers are a specific form of extracellular matrix composed mainly of fibrillins. The purpose of this study was to determine which cells secrete fibrillin-1 during development and aging. A specific guinea pig fibrillin-1 mRNA probe was designed and cloned in order to identify fibrillin-secreting cells in guinea pig eye, using in situ hybridization.(More)
In vergleichenden Untersuchungen wird durch Einsatz der Paraffinschnitt-Methode an gefärbten Präparaten die Identifizierung histologischer und cytologischer Strukturen an Kartoffelchips und-sticks und ihre Zuordnung zu Differenzierungen an ungeschälten rohen Knollen ermöglicht. Somit können an Rösterzeugnissen normale, zu jeder Kartoffelknolle gehörende(More)
Bet der mik roskop i schen B e o b a c h t u n g yon Getre ided / i n n s c h n i t t e n Igll t auf, dab die sog. Aleuronzel len ve r sch i eden tier in das S t ~ r k e e n d o s p e r m h ine in ragen . I m einschlXgigen S c h r i f t t u m f inden sich hiertf ir ke ine erkI&renden A n g a b e n . i h ren h o h e n Pro te ingeha l t . Dieses h a t also m(More)
I/inf durch Gold ausgel6ste Ra t t ensa rkome sowie u m zwei durch Gold, zwei durch P la t in a n d zwei du tch Elfenbein hervorgerufene M~usesarkome, insgesamt also u m bisher t7 mal igne Tumoren*) . Deren N a t u r sowie die Lokal i sadon u m ein I m p l a n t a t s ind in ke inem Fal le zweifelhaft . Teilweise lagen Metas tasen vor. T ransp lan ta t(More)